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    RRN5 Rrn5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850832, updated on 1-Aug-2024

    Summary

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    Gene symbol
    RRN5
    Gene description
    Rrn5p
    Primary source
    FungiDB:YLR141W
    Locus tag
    YLR141W
    See related
    SGD:S000004131; AllianceGenome:SGD:S000004131; VEuPathDB:YLR141W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA polymerase I general transcription initiation factor activity. Involved in chromatin organization and nucleolar large rRNA transcription by RNA polymerase I. Located in nucleolus. Part of RNA polymerase I upstream activating factor complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RRN5 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (423683..424774)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Nha1p Neighboring gene Sls1p Neighboring gene proline dehydrogenase Neighboring gene tRNA-Asp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA protein-interactions at the Saccharomyces cerevisiae 35 S rRNA promoter and in its surrounding region. Vogelauer M, et al. J Mol Biol, 1998 Jan 16. PMID 9466903
    2. RNA polymerase switch in transcription of yeast rDNA: role of transcription factor UAF (upstream activation factor) in silencing rDNA transcription by RNA polymerase II. Vu L, et al. Proc Natl Acad Sci U S A, 1999 Apr 13. PMID 10200272, Free PMC Article
    3. Histones are required for transcription of yeast rRNA genes by RNA polymerase I. Tongaonkar P, et al. Proc Natl Acad Sci U S A, 2005 Jul 19. PMID 16002464, Free PMC Article
    4. Histones H3 and H4 are components of upstream activation factor required for the high-level transcription of yeast rDNA by RNA polymerase I. Keener J, et al. Proc Natl Acad Sci U S A, 1997 Dec 9. PMID 9391047, Free PMC Article
    5. Multiprotein transcription factor UAF interacts with the upstream element of the yeast RNA polymerase I promoter and forms a stable preinitiation complex. Keys DA, et al. Genes Dev, 1996 Apr 1. PMID 8846924

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase I general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleolar large rRNA transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleolar large rRNA transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleolar large rRNA transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase I upstream activating factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase I upstream activating factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rrn5p
    NP_013242.1
    • Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      423683..424774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182028.1 → NP_013242.1  TPA: Rrn5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013242.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYD5, Q02983, Q12061
      UniProtKB/TrEMBL
      C8ZDB0, N1P6N4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02983.1

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