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    ARC15 Arc15p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854748, updated on 17-May-2024

    Summary

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    Gene symbol
    ARC15
    Gene description
    Arc15p
    Primary source
    FungiDB:YIL062C
    Locus tag
    YIL062C
    See related
    SGD:S000001324; AllianceGenome:SGD:S000001324; VEuPathDB:YIL062C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity and protein-macromolecule adaptor activity. Involved in actin cortical patch organization and mitochondrion inheritance. Is extrinsic component of mitochondrial outer membrane. Part of Arp2/3 protein complex. Orthologous to human ARPC5 (actin related protein 2/3 complex subunit 5) and ARPC5L (actin related protein 2/3 complex subunit 5 like). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARC15 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (243998..244462, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Efm4p Neighboring gene Yrb2p Neighboring gene U1 snRNP complex subunit SNP1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes. Qureshi MS, et al. Anal Biochem, 2013 Aug 1. PMID 23583819
    2. Purification of Arp2/3 complex from Saccharomyces cerevisiae. Doolittle LK, et al. Methods Mol Biol, 2013. PMID 23868593, Free PMC Article
    3. Functional surfaces on the p35/ARPC2 subunit of Arp2/3 complex required for cell growth, actin nucleation, and endocytosis. Daugherty KM, et al. J Biol Chem, 2008 Jun 13. PMID 18381280, Free PMC Article
    4. Mapping dynamic protein interactions in MAP kinase signaling using live-cell fluorescence fluctuation spectroscopy and imaging. Slaughter BD, et al. Proc Natl Acad Sci U S A, 2007 Dec 18. PMID 18077328, Free PMC Article
    5. Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions. Egile C, et al. PLoS Biol, 2005 Nov. PMID 16262445, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cortical patch organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Arc15p
    NP_012202.1
    • Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      243998..244462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179412.1 → NP_012202.1  TPA: Arc15p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012202.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVM2, P40518
      UniProtKB/TrEMBL
      A0A6L1AL46, A6ZVL1, B3LTR5, B5VKP0, C7GVY6, C8ZAI6, G2WG86, N1P9C9
      Conserved Domains (1) summary
      pfam04699
      Location:4 → 152
      P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40518.1

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