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    PKP2 protein kinase PKP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852821, updated on 9-Jun-2024

    Summary

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    Gene symbol
    PKP2
    Gene description
    protein kinase PKP2
    Primary source
    FungiDB:YGL059W
    Locus tag
    YGL059W
    See related
    SGD:S000003027; AllianceGenome:SGD:S000003027; VEuPathDB:YGL059W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including carbon utilization; negative regulation of pyruvate dehydrogenase activity; and regulation of mitophagy. Located in mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 6 and branched-chain keto acid dehydrogenase kinase deficiency. Orthologous to several human genes including BCKDK (branched chain keto acid dehydrogenase kinase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PKP2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (392223..393698)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Duo1p Neighboring gene Ybp2p Neighboring gene E2 ubiquitin-conjugating protein RAD6 Neighboring gene Gep7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of genes encoding pyruvate dehydrogenase kinases leads to retarded growth on acetate and ethanol in Saccharomyces cerevisiae. Steensma HY, et al. Yeast, 2008 Jan. PMID 17918780
    2. Strep-tag II and Twin-Strep based cassettes for protein tagging by homologous recombination and characterization of endogenous macromolecular assemblies in Saccharomyces cerevisiae. Rai J, et al. Mol Biotechnol, 2014 Nov. PMID 24969434
    3. Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. Gey U, et al. J Biol Chem, 2008 Apr 11. PMID 18180296
    4. Analysis of yeast protein kinases using protein chips. Zhu H, et al. Nat Genet, 2000 Nov. PMID 11062466
    5. Phosphorylation of mitochondrial matrix proteins regulates their selective mitophagic degradation. Kolitsida P, et al. Proc Natl Acad Sci U S A, 2019 Oct 8. PMID 31548421, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pkp2p (Ygl059wp) and Ppp2p (Ycr079wp), are engaged in the regulation of this complex by affecting the phosphorylation state of Pda1p.
      Title: Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase PKP2
    NP_011456.5
    • Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      392223..393698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180924.4 → NP_011456.5  TPA: protein kinase PKP2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011456.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU82, P53170
      UniProtKB/TrEMBL
      A0A8H4C1F6, A6ZUB7, B3LHC8, B5VIR5, C7GRJ5, C8Z8I8, G2WE37, N1P5H8
      Conserved Domains (2) summary
      cd16929
      Location:248 → 477
      HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
      pfam10436
      Location:79 → 239
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53170.3

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