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    MPC1 pyruvate transporter MPC1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852800, updated on 17-May-2024

    Summary

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    Gene symbol
    MPC1
    Gene description
    pyruvate transporter MPC1
    Primary source
    FungiDB:YGL080W
    Locus tag
    YGL080W
    See related
    SGD:S000003048; AllianceGenome:SGD:S000003048; VEuPathDB:YGL080W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FMP37
    Summary
    Enables pyruvate transmembrane transporter activity. Involved in mitochondrial pyruvate transmembrane transport. Is integral component of mitochondrial inner membrane. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in mitochondrial pyruvate carrier deficiency. Orthologous to several human genes including MPC1 (mitochondrial pyruvate carrier 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MPC1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (358636..359028)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Kxd1p Neighboring gene RNA-dependent ATPase DBP3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes. Wang Z, et al. Biomolecules, 2023 Apr 22. PMID 37238591, Free PMC Article
    2. Stress-seventy subfamily A 4, A member of HSP70, confers yeast cadmium tolerance in the loss of mitochondria pyruvate carrier 1. Li X, et al. Plant Signal Behav, 2020. PMID 31985324, Free PMC Article
    3. Repression of mitochondrial metabolism for cytosolic pyruvate-derived chemical production in Saccharomyces cerevisiae. Morita K, et al. Microb Cell Fact, 2019 Oct 15. PMID 31615527, Free PMC Article
    4. The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state. Tavoulari S, et al. EMBO J, 2019 May 15. PMID 30979775, Free PMC Article
    5. Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes. Bender T, et al. EMBO J, 2015 Apr 1. PMID 25672363, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes.
      Title: NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes.
    2. MPC is a hetero-dimer, not a multimeric complex. When not engaged in hetero-dimers, the yeast Mpc proteins can also form homo-dimers that are, however, inactive.
      Title: The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state.
    3. while expression of Mpc1 is not dependent on the carbon source, expression of Mpc2 and Mpc3 is specific to fermentative or respiratory conditions, respectively. This gives rise to two alternative carrier complexes
      Title: Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes.
    4. Mpc1 (YGL080W )and Mpc2 (YHR162W) associate to form a complex in the inner mitochondrial membrane; loss of Mpc1 results in defective mitochondrial pyruvate uptake; data demonstrate that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier
      Title: A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.
    5. study concludes that the mitochondrial pyruvate carrier is composed of Mpc1(Ygl080w) and either Mpc2 (Yhr162w) or Mpc3 (Ygr243w); members of the MPC family were found in the inner mitochondrial membrane; mutants lacking MPC proteins showed severe defects in mitochondrial pyruvate uptake
      Title: Identification and functional expression of the mitochondrial pyruvate carrier.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables pyruvate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyruvate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial pyruvate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial pyruvate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial pyruvate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial pyruvate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate transporter MPC1
    NP_011435.1
    • Highly conserved subunit of mitochondrial pyruvate carrier (MPC); MPC is a mitochondrial inner membrane complex that mediates pyruvate uptake and comprises Mpc1p and Mpc2p during fermentative growth, or Mcp1p and Mpc3p during respiratory growth; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog MPC1 is associated with lactic acidosis and hyperpyruvatemia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      358636..359028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180945.1 → NP_011435.1  TPA: pyruvate transporter MPC1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011435.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU64, P53157
      UniProtKB/TrEMBL
      A0A8H4FBF5, A6ZU99, B3LHE6, C7GW36, C8Z8G7, G2WE19, N1P5G4
      Conserved Domains (1) summary
      pfam03650
      Location:13 → 121
      MPC; Uncharacterized protein family (UPF0041)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53157.1

    Gene LinkOut

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