LPD1 dihydrolipoyl dehydrogenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: LPD1
Official Full Name: dihydrolipoyl dehydrogenase
Primary source: SGD:S000001876
Locus tag: YFL018C
See related: AllianceGenome:SGD:S000001876; FungiDB:YFL018C; VEuPathDB:YFL018C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HPD1
Summary: Enables dihydrolipoyl dehydrogenase activity; glycine dehydrogenase (decarboxylating) activity; and oxidoreductase activity, acting on the aldehyde or oxo group of donors. Involved in carboxylic acid metabolic process; cellular respiration; and hydrogen peroxide metabolic process. Located in mitochondrial nucleoid. Part of glycine cleavage complex; oxoglutarate dehydrogenase complex; and pyruvate dehydrogenase complex. Is active in mitochondrion. Used to study disease of metabolism. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DLD (dihydrolipoamide dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LPD1 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (101628..103127, complement)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

under elevated oxidative stress, expression of DLD proteins with dimer interface mutations greatly accelerated the loss of respiratory function, resulting from enhanced oxidative damage to the lipoic acid cofactor of pyruvate dehydrogenase
Title: Mutations in the dimer interface of dihydrolipoamide dehydrogenase promote site-specific oxidative damages in yeast and human cells.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dihydrolipoyl dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydrolipoyl dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables dihydrolipoyl dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables dihydrolipoyl dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables glycine dehydrogenase (decarboxylating) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxoglutarate dehydrogenase (succinyl-transferring) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pyruvate dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 2-oxoglutarate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-leucine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-serine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hydrogen peroxide metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hydrogen peroxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in isoleucine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyruvate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyruvate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in valine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of glycine cleavage complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of oxoglutarate dehydrogenase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of oxoglutarate dehydrogenase complex	IDA Inferred from Direct Assay more info	PubMed
part_of pyruvate dehydrogenase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dihydrolipoyl dehydrogenase

NP_116635.1

EC 1.8.1.4

Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes; LPD1 has a paralog, IRC15, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

101628..103127 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179948.1 → NP_116635.1 TPA: dihydrolipoyl dehydrogenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116635.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTL1, P09624

UniProtKB/TrEMBL

A7A220, B3LUJ0, B5VI12, G2WDC2, N1P4X6

Conserved Domains (1) summary

cl39093
Location:24 → 498

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase