CHO1 CDP-diacylglycerol-serine O-phosphatidyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CHO1
Official Full Name: CDP-diacylglycerol-serine O-phosphatidyltransferase
Primary source: SGD:S000000828
Locus tag: YER026C
See related: AllianceGenome:SGD:S000000828; FungiDB:YER026C; VEuPathDB:YER026C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PSS1
Summary: Enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity. Involved in phosphatidylserine biosynthetic process. Located in mitochondrial outer membrane. Orthologous to human TMEM269 (transmembrane protein 269). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CHO1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (207644..208474, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In this study, we found that Cho1p, like mammalian PS synthases is inhibited by its product, PS. This suggests a simple mechanism of activating Cho1p at membrane contact sites (MCSs); PS transport out of the ER at MCSs will stimulate Cho1p activity in these regions.
Title: Phosphatidylserine synthesis at membrane contact sites promotes its transport out of the ER.
overexpression of CHO1 suppresses defects in the endocytic recycling pathway in flippase mutants. These results suggest that flippase-dependent vesicle formation is mediated by phospholipid flipping.
Title: Role of phosphatidylserine in phospholipid flippase-mediated vesicle transport in Saccharomyces cerevisiae.
phosphatidylserine synthase is phosphorylated on Ser(46) and Ser(47) by protein kinase A, which results in a higher amount of enzyme for the net effect of stimulating the synthesis of phosphatidylserine
Title: Phosphorylation of yeast phosphatidylserine synthase by protein kinase A: identification of Ser46 and Ser47 as major sites of phosphorylation.
Respiratory deficiency mediates the regulation of CHO1 by mRNA stability in Saccharomyces cerevisiae.
Title: Respiratory deficiency mediates the regulation of CHO1-encoded phosphatidylserine synthase by mRNA stability in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphotransferase activity, for other substituted phosphate groups	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylserine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylserine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CDP-diacylglycerol-serine O-phosphatidyltransferase

NP_010943.3

EC 2.7.8.8

Phosphatidylserine synthase; functions in phospholipid biosynthesis; transcriptionally repressed by myo-inositol and choline

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

207644..208474 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178917.3 → NP_010943.3 TPA: CDP-diacylglycerol-serine O-phosphatidyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010943.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLS5, P08456

UniProtKB/TrEMBL

A6ZQX5, B3LS39, C7GSH3, G2WCQ9, N1P5S6

Conserved Domains (1) summary

TIGR00473
Location:87 → 242

pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase