RGA2 GTPase-activating protein RGA2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: RGA2
Official Full Name: GTPase-activating protein RGA2
Primary source: SGD:S000002787
Locus tag: YDR379W
See related: AllianceGenome:SGD:S000002787; FungiDB:YDR379W; VEuPathDB:YDR379W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables GTPase activator activity. Involved in positive regulation of GTPase activity; septin ring organization; and small GTPase mediated signal transduction. Located in cellular bud neck split septin rings. Human ortholog(s) of this gene implicated in Duane retraction syndrome. Orthologous to human CHN1 (chimerin 1) and CHN2 (chimerin 2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables GTPase activator activity	ISA Inferred from Sequence Alignment more info	PubMed
enables GTPase regulator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in septin ring organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in septin ring organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cellular bud	IBA Inferred from Biological aspect of Ancestor more info
located_in cellular bud	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck split septin rings	IDA Inferred from Direct Assay more info	PubMed
is_active_in mating projection tip	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_010667.1

GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p; RGA2 has a paralog, RGA1, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain