HEM25 Hem25p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: HEM25
Gene description: Hem25p
Primary source: FungiDB:YDL119C
Locus tag: YDL119C
See related: SGD:S000002277; AllianceGenome:SGD:S000002277; VEuPathDB:YDL119C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glycine transmembrane transporter activity. Involved in glycine import into mitochondrion and heme biosynthetic process. Located in mitochondrion. Used to study sideroblastic anemia. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 2. Orthologous to human SLC25A38 (solute carrier family 25 member 38). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glycine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glycine transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables glycine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in glycine import into mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine import into mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in glycine import into mitochondrion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glycine import into mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heme biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_010164.1

Mitochondrial glycine transporter; required for the transport of glycine into mitochondria for initiation of heme biosynthesis, with YMC1 acting as a secondary transporter; homolog of human SLC25A38, a mitochondrial glycine transporter associated with nonsyndromic autosomal recessive congenital sideroblastic anemia; human SLC25A38 can complement the heme deficiency associated with the null mutant; GFP-fusion protein is induced in response to the DNA-damaging agent MMS