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    GRS1 glycine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852418, updated on 26-Jun-2024

    Summary

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    Gene symbol
    GRS1
    Gene description
    glycine--tRNA ligase
    Primary source
    FungiDB:YBR121C
    Locus tag
    YBR121C
    See related
    SGD:S000000325; AllianceGenome:SGD:S000000325; VEuPathDB:YBR121C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glycine-tRNA ligase activity. Involved in DNA-templated transcription, termination and mitochondrial glycyl-tRNA aminoacylation. Located in mitochondrion. Used to study Charcot-Marie-Tooth disease type 2D. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and distal hereditary motor neuronopathy type 5A. Orthologous to human GARS1 (glycyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GRS1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (481364..483367, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Mud1p Neighboring gene Cbp6p Neighboring gene mitochondrial 54S ribosomal protein YmL36 Neighboring gene transcription factor TFIIIC subunit TFC1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional substitution of a eukaryotic glycyl-tRNA synthetase with an evolutionarily unrelated bacterial cognate enzyme. Chien CI, et al. PLoS One, 2014. PMID 24743154, Free PMC Article
    2. Translational efficiency of a non-AUG initiation codon is significantly affected by its sequence context in yeast. Chen SJ, et al. J Biol Chem, 2008 Feb 8. PMID 18065417
    3. Translation initiation from a naturally occurring non-AUG codon in Saccharomyces cerevisiae. Chang KJ, et al. J Biol Chem, 2004 Apr 2. PMID 14734560
    4. GRS1, a yeast tRNA synthetase with a role in mRNA 3' end formation. Johanson K, et al. J Biol Chem, 2003 Sep 19. PMID 12855679
    5. A mutation in GRS1, a glycyl-tRNA synthetase, affects 3'-end formation in Saccharomyces cerevisiae. Magrath C, et al. Genetics, 1999 May. PMID 10224248, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP:ATP adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity, acting on a tRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycine-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription termination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycyl-tRNA aminoacylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial glycyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial glycyl-tRNA aminoacylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycine--tRNA ligase
    NP_009679.2
    • Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication; human homolog GARS implicated in Charcot-Marie-Tooth disease, can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      481364..483367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178469.2 → NP_009679.2  TPA: glycine--tRNA ligase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009679.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8H4BU00, B3LN34, B5VE81, C7GY06, G2W9C6, N1PAT2
      Conserved Domains (1) summary
      TIGR00389
      Location:15 → 640
      glyS_dimeric; glycyl-tRNA synthetase, dimeric type
    Nucleotide Protein
    Heading Accession and Version

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