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    NHP6A high-mobility group nucleosome-binding protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856165, updated on 29-Jun-2024

    Summary

    Gene symbol
    NHP6A
    Gene description
    high-mobility group nucleosome-binding protein
    Primary source
    FungiDB:YPR052C
    Locus tag
    YPR052C
    See related
    SGD:S000006256; AllianceGenome:SGD:S000006256; VEuPathDB:YPR052C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA binding activity, bending; MutSalpha complex binding activity; and nucleosome binding activity. Involved in chromatin organization; negative regulation of DNA binding activity; and transcription, DNA-templated. Located in nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and syndromic microphthalmia 13. Orthologous to human HMGB1 (high mobility group box 1); HMGB2 (high mobility group box 2); and HMGB3 (high mobility group box 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See NHP6A in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (665693..665974, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene autophagy protein ATG11 Neighboring gene peptide alpha-N-acetyltransferase MAK3 Neighboring gene uncharacterized protein Neighboring gene mitogen-activated protein kinase SMK1 Neighboring gene exocyst subunit SEC8

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MutSalpha complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    high-mobility group nucleosome-binding protein
    NP_015377.1
    • High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      665693..665974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184149.1NP_015377.1  TPA: high-mobility group nucleosome-binding protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015377.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W459, P11632
      UniProtKB/TrEMBL
      G2W997, N1NWB4
      Conserved Domains (1) summary
      COG5648
      Location:193
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]