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    TCO89 Tco89p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855922, updated on 17-May-2024

    Summary

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    Gene symbol
    TCO89
    Gene description
    Tco89p
    Primary source
    FungiDB:YPL180W
    Locus tag
    YPL180W
    See related
    SGD:S000006101; AllianceGenome:SGD:S000006101; VEuPathDB:YPL180W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in several processes, including fungal-type cell wall organization; glycerol metabolic process; and response to salt stress. Located in fungal-type vacuole membrane. Is extrinsic component of cytoplasmic side of plasma membrane and extrinsic component of vacuolar membrane. Part of TORC1 complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TCO89 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (205248..207647)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rtt10p Neighboring gene Cti6p Neighboring gene protein-serine/threonine phosphatase Neighboring gene tRNA-Glu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a functional Candida albicans homolog of the Saccharomyces cerevisiae TCO89 gene. Zheng C, et al. FEMS Yeast Res, 2007 Jun. PMID 17298473
    2. GUP1 and its close homologue GUP2, encoding multimembrane-spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae. Holst B, et al. Mol Microbiol, 2000 Jul. PMID 10931309
    3. TORC1 Determines Fab1 Lipid Kinase Function at Signaling Endosomes and Vacuoles. Chen Z, et al. Curr Biol, 2021 Jan 25. PMID 33157024
    4. TOR complex 1 regulates the yeast plasma membrane proton pump and pH and potassium homeostasis. Mahmoud S, et al. FEBS Lett, 2017 Jul. PMID 28486745
    5. TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor. MacGurn JA, et al. Cell, 2011 Nov 23. PMID 22118465

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results implicated an important regulatory role of TCO89 and TORCI in this pathway.
      Title: Regulation of Vid-dependent degradation of FBPase by TCO89, a component of TOR Complex 1.
    2. Vam6 controls TORC1(Tco89) function by activating the Gtr1 subunit of the EGO complex.
      Title: The Vam6 GEF controls TORC1 by activating the EGO complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell growth IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TORC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TORC1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tco89p
    NP_015145.1
    • Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      205248..207647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183994.1 → NP_015145.1  TPA: Tco89p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015145.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3I8, Q08921
      UniProtKB/TrEMBL
      A0A8H4BTZ6, A6ZW73, B3LKP8, B5VSZ2, C7GJC9, N1P2P2
      Conserved Domains (1) summary
      pfam10452
      Location:30 → 732
      TCO89; TORC1 subunit TCO89
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08921.1

    Gene LinkOut

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