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    TPP1 polynucleotide 3'-phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855188, updated on 28-Oct-2024

    Summary

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    Official Symbol
    TPP1
    Official Full Name
    polynucleotide 3'-phosphatase
    Primary source
    SGD:S000004765
    Locus tag
    YMR156C
    See related
    AllianceGenome:SGD:S000004765; FungiDB:YMR156C; VEuPathDB:YMR156C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables double-stranded DNA binding activity and polynucleotide 3'-phosphatase activity. Involved in double-strand break repair. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B2; ataxia-oculomotor apraxia type 4; and microcephaly, seizures, and developmental delay. Orthologous to human PNKP (polynucleotide kinase 3'-phosphatase). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See TPP1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (570300..571016, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Rim13p Neighboring gene uncharacterized protein Neighboring gene Aim36p Neighboring gene mitochondrial 37S ribosomal protein MRPS8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of DNA 3'-phosphatase active site residues and their differential role in DNA binding, Mg2+ coordination, and catalysis. Deshpande RA, et al. Biochemistry, 2004 Jul 6. PMID 15222769
    2. Uncoupling of 3'-phosphatase and 5'-kinase functions in budding yeast. Characterization of Saccharomyces cerevisiae DNA 3'-phosphatase (TPP1). Vance JR, et al. J Biol Chem, 2001 May 4. PMID 11278831
    3. Yeast Tdp1 regulates the fidelity of nonhomologous end joining. Bahmed K, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160111, Free PMC Article
    4. Error-free and mutagenic processing of topoisomerase 1-provoked damage at genomic ribonucleotides. Sparks JL, et al. EMBO J, 2015 May 5. PMID 25777529, Free PMC Article
    5. Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatases. Vance JR, et al. Mol Cell Biol, 2001 Nov. PMID 11585902, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polynucleotide 3'-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polynucleotide 3'-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polynucleotide 3'-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polynucleotide 3'-phosphatase
    NP_013877.1
    • DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3'-phosphatase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      570300..571016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182659.1 → NP_013877.1  TPA: polynucleotide 3'-phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013877.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZX7, Q03796
      UniProtKB/TrEMBL
      A6ZML4, B3LM43, B5VPS8, C7GQ95, C8ZF14, G2WKK7, N1NYH0
      Conserved Domains (1) summary
      cl21460
      Location:30 → 236
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03796.1

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