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    Slc24a1 solute carrier family 24 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56814, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Slc24a1provided by RGD
    Official Full Name
    solute carrier family 24 member 1provided by RGD
    Primary source
    RGD:620080
    See related
    EnsemblRapid:ENSRNOG00000052051 AllianceGenome:RGD:620080
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nckx1
    Summary
    Enables calcium, potassium:sodium antiporter activity. Involved in calcium ion transmembrane transport. Is intrinsic component of plasma membrane. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1D. Orthologous to human SLC24A1 (solute carrier family 24 member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 6.1), Brain (RPKM 2.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc24a1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (74334556..74361313, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (65440842..65466001, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (70409683..70438352, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548661 Neighboring gene DENN domain containing 4A Neighboring gene small nucleolar RNA SNORA17 Neighboring gene integrator complex subunit 14 Neighboring gene 3-hydroxyacyl-CoA dehydratase 3 Neighboring gene ATP synthase membrane subunit DAPIT, mitochondrial-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential expression of Na/Ca exchanger and Na/Ca + K exchanger transcripts in rat brain. Li XF, et al. Ann N Y Acad Sci, 2002 Nov. PMID 12502535
    2. Alternatively spliced isoforms of the rat eye sodium/calcium+potassium exchanger NCKX1. Poon S, et al. Am J Physiol Cell Physiol, 2000 Apr. PMID 10751314
    3. Alteration of intracellular calcium and its modulator SLC24A6 after experimental intracerebral hemorrhage. Zheng M, et al. Acta Neurochir Suppl, 2013. PMID 23564126
    4. Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles. Altimimi HF, et al. Channels (Austin), 2007 Mar-Apr. PMID 18690016
    5. Cation dependencies and turnover rates of the human K⁺-dependent Na⁺-Ca²⁺ exchangers NCKX1, NCKX2, NCKX3 and NCKX4. Jalloul AH, et al. Cell Calcium, 2016 Jan. PMID 26631410

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential expression in the rat brain
      Title: Differential expression of Na/Ca exchanger and Na/Ca + K exchanger transcripts in rat brain.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium, potassium:sodium antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-term synaptic depression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-term synaptic potentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium/potassium/calcium exchanger 1
    Names
    Na(+)/K(+)/Ca(2+)-exchange protein 1
    retinal Na/Ca,K exchanger
    retinal rod Na-Ca+K exchanger
    sodium/calcium/potassium exchanger
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020090.1 → NP_064475.1  sodium/potassium/calcium exchanger 1

      See identical proteins and their annotated locations for NP_064475.1

      Status: PROVISIONAL

      Source sequence(s)
      AF176688
      UniProtKB/Swiss-Prot
      Q62932, Q9QZM6
      UniProtKB/TrEMBL
      A0A0G2K8E1
      Related
      ENSRNOP00000074571.2, ENSRNOT00000077152.3
      Conserved Domains (4) summary
      TIGR00927
      Location:1 → 1181
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam01699
      Location:1018 → 1169
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03247
      Location:837 → 918
      Prothymosin; Prothymosin/parathymosin family
      cl22451
      Location:746 → 866
      ASF1_hist_chap; ASF1 like histone chaperone

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      74334556..74361313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266044.1 → XP_063122114.1  sodium/potassium/calcium exchanger 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8E1
      Related
      ENSRNOP00000091100.1, ENSRNOT00000101835.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZM6.1 GenPept UniProtKB/Swiss-Prot:Q9QZM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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