MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MICAL1provided by HGNC
Official Full Name: microtubule associated monooxygenase, calponin and LIM domain containing 1provided by HGNC
Primary source: HGNC:HGNC:20619
See related: Ensembl:ENSG00000135596 MIM:607129; AllianceGenome:HGNC:20619
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MICAL; NICAL; MICAL-1
Summary: This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression: Ubiquitous expression in bone marrow (RPKM 31.4), lymph node (RPKM 25.8) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q21

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (109444062..109465968, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (110622100..110644006, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (109765265..109787171, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner.
Title: PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner.
High MICAL1 expression correlates with cancer progression and immune infiltration in renal clear cell carcinoma.
Title: High MICAL1 expression correlates with cancer progression and immune infiltration in renal clear cell carcinoma.
Mical modulates Tau toxicity via cysteine oxidation in vivo.
Title: Mical modulates Tau toxicity via cysteine oxidation in vivo.
MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/beta-catenin signaling pathway.
Title: MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/β-catenin signaling pathway.
MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours.
Title: MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours.
GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508.
Title: GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508.
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
Title: MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
Human MICAL1: Activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8.
Title: Human MICAL1: Activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8.
our results suggest that MICAL1 exhibits its effect on proliferation via maintaining cyclin D expression through ROS-sensitive PI3K/Akt/ERK signalling in breast cancer cells
Title: MICAL1 facilitates breast cancer cell proliferation via ROS-sensitive ERK/cyclin D pathway.
Two autosomal-dominant lateral temporal epilepsy-causing variants were identified in the MICAL1 gene.
Title: Mutations in MICAL-1cause autosomal-dominant lateral temporal epilepsy.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Epilepsy, familial temporal lobe, 1 MedGen: C4551957 OMIM: 600512 GeneReviews: Autosomal Dominant Epilepsy with Auditory Features	not available

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables F-actin monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables FAD binding	IDA Inferred from Direct Assay more info	PubMed
enables NAD(P)H oxidase H2O2-forming activity	IDA Inferred from Direct Assay more info	PubMed
enables NADPH oxidase H202-forming activity	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of regulated secretory pathway	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in sulfur oxidation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in hippocampal mossy fiber expansion	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	NAS Non-traceable Author Statement more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: [F-actin]-monooxygenase MICAL1

Names: NEDD9-interacting protein with calponin homology and LIM domains; [F-actin]-methionine sulfoxide oxidase MICAL1; molecule interacting with CasL protein 1; protein-methionine sulfoxide oxidase MICAL1

NP_001152763.1

EC 1.14.13.225

EC 1.6.3.1

NP_001273542.1

EC 1.14.13.225

EC 1.6.3.1

NP_073602.3

EC 1.14.13.225

EC 1.6.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_042833.1 RefSeqGene

Range

15197..26907

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001159291.2 → NP_001152763.1 [F-actin]-monooxygenase MICAL1 isoform 2

See identical proteins and their annotated locations for NP_001152763.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' exon and thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, and it lacks an alternate in-frame exon in the central coding region, compared to variant 3. The encoded isoform (2, also known as MICAL-1b) is shorter at the N-terminus, compared to isoform 3.

Source sequence(s)

AB048948, BC009972, BC042144

Consensus CDS

CCDS55047.1

UniProtKB/TrEMBL

A0A1S5UZH2

Related

ENSP00000351385.3, ENST00000358577.7

Conserved Domains (5) summary

cd09358
Location:611 → 664

LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family

pfam00307
Location:425 → 521

CH; Calponin homology (CH) domain

pfam12130
Location:841 → 974

DUF3585; Protein of unknown function (DUF3585)

pfam13450
Location:89 → 116

NAD_binding_8; NAD(P)-binding Rossmann-like domain

pfam16602
Location:527 → 607

USP19_linker; Linker region of USP19 deubiquitinase
NM_001286613.2 → NP_001273542.1 [F-actin]-monooxygenase MICAL1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transrcript and encodes the longest isoform (3).

Source sequence(s)

AK296284, AL109947, BC042144

Consensus CDS

CCDS69170.1

UniProtKB/TrEMBL

A0A1S5UZH2

Related

ENSP00000486901.1, ENST00000630715.2

Conserved Domains (5) summary

cd09358
Location:716 → 769

LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family

pfam00307
Location:530 → 626

CH; Calponin homology (CH) domain

pfam12130
Location:946 → 1079

DUF3585; Protein of unknown function (DUF3585)

pfam13450
Location:108 → 135

NAD_binding_8; NAD(P)-binding Rossmann-like domain

pfam16602
Location:632 → 712

USP19_linker; Linker region of USP19 deubiquitinase
NM_022765.4 → NP_073602.3 [F-actin]-monooxygenase MICAL1 isoform 1

See identical proteins and their annotated locations for NP_073602.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) contains an alternate 5' exon and thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 3. The encoded isoform (1, also known as MICAL-1a) is shorter at the N-terminus, compared to isoform 3.

Source sequence(s)

BC042144

Consensus CDS

CCDS5076.1

UniProtKB/Swiss-Prot

B7Z3R5, E1P5F0, Q7Z633, Q8IVS9, Q8TDZ2, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7

UniProtKB/TrEMBL

A0A1S5UZH2

Related

ENSP00000351664.3, ENST00000358807.8

Conserved Domains (5) summary

cd09358
Location:697 → 750

LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family

pfam00307
Location:511 → 607

CH; Calponin homology (CH) domain

pfam12130
Location:927 → 1060

DUF3585; Protein of unknown function (DUF3585)

pfam13450
Location:89 → 116

NAD_binding_8; NAD(P)-binding Rossmann-like domain

pfam16602
Location:613 → 693

USP19_linker; Linker region of USP19 deubiquitinase