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    ZNF839 zinc finger protein 839 [ Homo sapiens (human) ]

    Gene ID: 55778, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF839provided by HGNC
    Official Full Name
    zinc finger protein 839provided by HGNC
    Primary source
    HGNC:HGNC:20345
    See related
    Ensembl:ENSG00000022976 AllianceGenome:HGNC:20345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C14orf131
    Summary
    Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 6.0), spleen (RPKM 2.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF839 in Genome Data Viewer
    Location:
    14q32.31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102317506..102342367)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (96553100..96577964)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102783843..102808704)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene WD repeat domain 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102697452-102697952 Neighboring gene MOK protein kinase Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:102745661-102746860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102771382-102771904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102780520-102781020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9070 Neighboring gene tRNA-Ile (anticodon AAT) 5-4 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6115 Neighboring gene uncharacterized LOC124903389 Neighboring gene uncharacterized LOC124903440 Neighboring gene cyclin dependent kinase 2 interacting protein Neighboring gene tectonin beta-propeller repeat containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Polymorphisms in MicroRNA Binding Sites Predict Colorectal Cancer Survival. Yang YP, et al. Int J Med Sci, 2017. PMID 28138309, Free PMC Article
    2. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. Scanlan MJ, et al. Int J Cancer, 1999 Nov 12. PMID 10508479
    3. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. Achuthankutty D, et al. J Cell Biol, 2019 Dec 2. PMID 31615875, Free PMC Article
    4. Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. Daakour S, et al. BMC Cancer, 2016 May 26. PMID 27229929, Free PMC Article
    5. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF839 single nucleotide polymorphism association with colorectal cancer patients survival
      Title: Polymorphisms in MicroRNA Binding Sites Predict Colorectal Cancer Survival.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11132, FLJ33514

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 839
    Names
    renal carcinoma antigen NY-REN-50

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267827.2 → NP_001254756.1  zinc finger protein 839 isoform 2

      See identical proteins and their annotated locations for NP_001254756.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 5' coding region compared to variant 1, which results in the use of a downstream translation start codon. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AL137229, AL352978
      Consensus CDS
      CCDS58336.1
      UniProtKB/Swiss-Prot
      A8K0R7, B3KSD2, Q53FH5, Q6GPI5, Q86TU1, Q9BQ86, Q9NUU3
      Related
      ENSP00000453363.1, ENST00000558850.5
      Conserved Domains (1) summary
      pfam15961
      Location:7 → 804
      DUF4764; Domain of unknown function (DUF4764)

    2. NM_001267828.2 → NP_001254757.1  zinc finger protein 839 isoform 2

      See identical proteins and their annotated locations for NP_001254757.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the 5' coding region compared to variant 1, which results in the use of a downstream translation start codon. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AL137229, AL352978
      Consensus CDS
      CCDS58336.1
      UniProtKB/Swiss-Prot
      A8K0R7, B3KSD2, Q53FH5, Q6GPI5, Q86TU1, Q9BQ86, Q9NUU3
      Related
      ENSP00000453109.1, ENST00000559185.5
      Conserved Domains (1) summary
      pfam15961
      Location:7 → 804
      DUF4764; Domain of unknown function (DUF4764)

    3. NM_001385065.1 → NP_001371994.1  zinc finger protein 839 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL137229, AL352978
      Conserved Domains (1) summary
      pfam15961
      Location:123 → 870
      DUF4764; Domain of unknown function (DUF4764)

    4. NM_001385069.1 → NP_001371998.1  zinc finger protein 839 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL137229, AL352978
      Conserved Domains (1) summary
      pfam15961
      Location:7 → 799
      DUF4764; Domain of unknown function (DUF4764)

    5. NM_001385070.1 → NP_001371999.1  zinc finger protein 839 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL137229, AL352978
      Conserved Domains (1) summary
      pfam15961
      Location:7 → 754
      DUF4764; Domain of unknown function (DUF4764)

    6. NM_001385071.1 → NP_001372000.1  zinc finger protein 839 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL137229, AL352978
      Conserved Domains (1) summary
      pfam15961
      Location:7 → 729
      DUF4764; Domain of unknown function (DUF4764)

    7. NM_001385072.1 → NP_001372001.1  zinc finger protein 839 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL137229, AL352978
      Conserved Domains (1) summary
      pfam15961
      Location:123 → 643
      DUF4764; Domain of unknown function (DUF4764)

    8. NM_001385073.1 → NP_001372002.1  zinc finger protein 839 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL137229, AL352978
      Conserved Domains (1) summary
      pfam15961
      Location:123 → 593
      DUF4764; Domain of unknown function (DUF4764)

    9. NM_001385074.1 → NP_001372003.1  zinc finger protein 839 isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 11 and 12, encodes isoform 9.
      Source sequence(s)
      AL137229, AL352978
      Conserved Domains (1) summary
      pfam15961
      Location:7 → 527
      DUF4764; Domain of unknown function (DUF4764)

    10. NM_001385075.1 → NP_001372004.1  zinc finger protein 839 isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 10 and 12, encodes isoform 9.
      Source sequence(s)
      AL137229, AL352978
      Conserved Domains (1) summary
      pfam15961
      Location:7 → 527
      DUF4764; Domain of unknown function (DUF4764)

    11. NM_001385076.1 → NP_001372005.1  zinc finger protein 839 isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 10 and 11, encodes isoform 9.
      Source sequence(s)
      AL137229, AL352978
      Conserved Domains (1) summary
      pfam15961
      Location:7 → 527
      DUF4764; Domain of unknown function (DUF4764)

    12. NM_018335.6 → NP_060805.3  zinc finger protein 839 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL137229, AL352978
      Consensus CDS
      CCDS45164.1
      UniProtKB/Swiss-Prot
      A8K0R7
      Related
      ENSP00000399863.2, ENST00000442396.7
      Conserved Domains (1) summary
      pfam15961
      Location:123 → 920
      DUF4764; Domain of unknown function (DUF4764)

    RNA

    1. NR_169565.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137229, AL352978

    2. NR_169566.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137229, AL352978

    3. NR_169567.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137229, AL352978

    4. NR_169568.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137229, AL352978

    5. NR_169569.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137229, AL352978
      Related
      ENST00000559098.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      102317506..102342367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536945.2 → XP_011535247.1  zinc finger protein 839 isoform X1

      Conserved Domains (1) summary
      pfam15961
      Location:157 → 954
      DUF4764; Domain of unknown function (DUF4764)

    2. XM_011536949.4 → XP_011535251.1  zinc finger protein 839 isoform X5

      Conserved Domains (1) summary
      pfam15961
      Location:157 → 694
      DUF4764; Domain of unknown function (DUF4764)

    3. XM_011536946.4 → XP_011535248.1  zinc finger protein 839 isoform X2

      Conserved Domains (1) summary
      pfam15961
      Location:157 → 904
      DUF4764; Domain of unknown function (DUF4764)

    4. XM_011536950.4 → XP_011535252.1  zinc finger protein 839 isoform X6

      Conserved Domains (1) summary
      pfam15961
      Location:157 → 644
      DUF4764; Domain of unknown function (DUF4764)

    5. XM_006720203.4 → XP_006720266.2  zinc finger protein 839 isoform X4

    6. XM_011536948.3 → XP_011535250.2  zinc finger protein 839 isoform X3

    7. XM_017021449.3 → XP_016876938.1  zinc finger protein 839 isoform X7

      UniProtKB/TrEMBL
      H0YM06
      Related
      ENSP00000453415.1, ENST00000559155.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      96553100..96577964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376370.1 → XP_054232345.1  zinc finger protein 839 isoform X1

    2. XM_054376374.1 → XP_054232349.1  zinc finger protein 839 isoform X5

    3. XM_054376371.1 → XP_054232346.1  zinc finger protein 839 isoform X2

    4. XM_054376375.1 → XP_054232350.1  zinc finger protein 839 isoform X6

    5. XM_054376373.1 → XP_054232348.1  zinc finger protein 839 isoform X4

    6. XM_054376372.1 → XP_054232347.1  zinc finger protein 839 isoform X3

    7. XM_054376376.1 → XP_054232351.1  zinc finger protein 839 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8K0R7.1 GenPept UniProtKB/Swiss-Prot:A8K0R7

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