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    dpy-2 Cuticle collagen dpy-2 [ Caenorhabditis elegans ]

    Gene ID: 174107, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dpy-2
    Official Full Name
    Cuticle collagen dpy-2
    Primary source
    WormBase:WBGene00001064
    Locus tag
    CELE_T14B4.6
    See related
    AllianceGenome:WB:WBGene00001064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle; post-embryonic body morphogenesis; and regulation of growth. Predicted to be part of collagen trimer. Is expressed in head neurons and pharynx. Used to study skin disease. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See dpy-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (6714292..6715971)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel mode of ecdysozoan growth in Caenorhabditis elegans. Knight CG, et al. Evol Dev, 2002 Jan-Feb. PMID 11871396
    2. Somatic polyploidization and cellular proliferation drive body size evolution in nematodes. Flemming AJ, et al. Proc Natl Acad Sci U S A, 2000 May 9. PMID 10805788, Free PMC Article
    3. The FDA-approved drugs ticlopidine, sertaconazole, and dexlansoprazole can cause morphological changes in C. elegans. Galford KF, et al. Chemosphere, 2020 Dec. PMID 32731027, Free PMC Article
    4. Loss of dpy-2 and dpy-9 has stage-specific effects on DBL-1 pathway signaling. Lakdawala MF, et al. MicroPubl Biol, 2019 Dec 9. PMID 32550453, Free PMC Article
    5. A mutation in a cuticle collagen causes hypersensitivity to the endocrine disrupting chemical, bisphenol A, in Caenorhabditis elegans. Watanabe M, et al. Mutat Res, 2005 Feb 15. PMID 15680404

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of collagen and cuticulin-based cuticle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of collagen trimer ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cuticle collagen dpy-2
    NP_495367.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6714292..6715971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062966.9 → NP_495367.1  Cuticle collagen dpy-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495367.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35799, Q22477
      Conserved Domains (2) summary
      pfam01391
      Location:172 → 228
      Collagen; Collagen triple helix repeat (20 copies)
      smart01088
      Location:26 → 78
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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