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    gst-24 Glutathione S-transferase [ Caenorhabditis elegans ]

    Gene ID: 185407, updated on 19-Jun-2024

    Summary

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    Gene symbol
    gst-24
    Gene description
    Glutathione S-transferase
    Locus tag
    CELE_F37B1.1
    See related
    AllianceGenome:WB:WBGene00001772
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione transferase activity. Involved in innate immune response. Is expressed in head and tail. Orthologous to human HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See gst-24 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003280.10 (13610443..13611366, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Caspase A subunit p16 Neighboring gene Glutathione S-transferase Neighboring gene Glutathione S-transferase Neighboring gene Glutathione transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Benzo-α-pyrene induced oxidative stress in Caenorhabditis elegans and the potential involvements of microRNA. Wu H, et al. Chemosphere, 2015 Nov. PMID 26291679
    2. Tris(1,3-dichloro-2-propyl) phosphate accelerated the aging process induced by the 4-hydroxynon-2-enal response to reactive oxidative species in Caenorhabditis elegans. Wang C, et al. Environ Pollut, 2019 Mar. PMID 31159140
    3. Ageing and oxidants in the nematode Caenorhabditis elegans. Gems D. SEB Exp Biol Ser, 2009. PMID 19418991
    4. Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal. Ayyadevara S, et al. Mech Ageing Dev, 2007 Feb. PMID 17157356, Free PMC Article
    5. Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR. Styer KL, et al. Science, 2008 Oct 17. PMID 18801967, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response HEP PubMed 

    General protein information

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    Preferred Names
    Glutathione S-transferase
    NP_496859.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13610443..13611366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064458.6 → NP_496859.1  Glutathione S-transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496859.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93694
      Conserved Domains (3) summary
      PTZ00057
      Location:6 → 208
      PTZ00057; glutathione s-transferase; Provisional
      cd03192
      Location:85 → 191
      GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases
      cd03039
      Location:4 → 75
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
    Nucleotide Protein
    Heading Accession and Version

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