Mgp matrix Gla protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mgpprovided by RGD
Official Full Name: matrix Gla proteinprovided by RGD
Primary source: RGD:3088
See related: Ensembl:ENSRNOG00000005695 AllianceGenome:RGD:3088
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mglap
Summary: Enables calcium ion binding activity and calcium-dependent protein binding activity. Involved in several processes, including branching morphogenesis of an epithelial tube; response to calcium ion; and response to glucocorticoid. Located in collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in arteriosclerosis; calcinosis; and myocardial infarction. Orthologous to human MGP (matrix Gla protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 2302.9), Lung (RPKM 1573.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q43

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (171497472..171500888, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (169766290..169769612, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (170856783..170860105, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

high proliferative glioma cells expressing a high level of MGP may exist and contribute to tumor infiltration and recurrence.
Title: Functional Role of Matrix gla Protein in Glioma Cell Migration.
Contiuous expression of Matrix Gla protein contributes to crystal formation in kidney of hyperoxaluric animals.
Title: Matrix Gla protein is involved in crystal formation in kidney of hyperoxaluric rats.
reduced gamma-Carboxylated MGP (cMGP), through an impaired expression of gamma-carboxylase, is involved in the early development of Medial artery calcification (MAC)in diabetes.
Title: Decreased expression of γ-carboxylase in diabetes-associated arterial stiffness: impact on matrix Gla protein.
Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein
Title: Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein.
Synthesis of MGP is increased in renal failure and deficiency of GlaMGP is not a primary cause of medial calcification in this condition.
Title: Matrix Gla protein metabolism in vascular smooth muscle and role in uremic vascular calcification.
Selective CaSR activation, either by extracellular calcium or AMG 641, increased MGP expression in vivo in the arterial wall and in vitro in bovine vascular smooth muscle cells.
Title: Effect of calcium and the calcimimetic AMG 641 on matrix-Gla protein in vascular smooth muscle cells.
Matrix Gla protein expression is up-regulated in NRK-52E (rat kidney tubular epithelial) cells exposed to oxalate and calcium oxalate monohydrate crystals.
Title: Matrix Gla protein expression in NRK-52E cells exposed to oxalate and calcium oxalate monohydrate crystals.
administration of intermedin inhibits vascular calcification development by increasing cMGP levels
Title: Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein.
MGP is rapidly upregulated in response to cardiac overload well before the development of LV hypertrophy and post-infarction remodeling process
Title: Upregulation of cardiac matrix Gla protein expression in response to hypertrophic stimuli.
Immunological rejection is likely to inhibit MGP expression in cryopreserved vascular allografts.
Title: Relationship between immunological rejection and matrix GLA protein in cryopreserved vascular allografts.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94560 (e-PCR)
- UniSTS:119808

Mgp (e-PCR), detects polymorphism
- UniSTS:516103

Mgp (e-PCR), detects polymorphism
- UniSTS:507066

RH127843 (e-PCR)
- UniSTS:211153

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in branching morphogenesis of an epithelial tube	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in ossification	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein-containing complex assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: matrix Gla protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012862.2 → NP_036994.2 matrix Gla protein precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P08494

UniProtKB/TrEMBL

F7FN71, Q5RK05

Related

ENSRNOP00000007577.2, ENSRNOT00000007577.6

Conserved Domains (1) summary

cl02449
Location:32 → 96

Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain