Tspan8 tetraspanin 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tspan8provided by RGD
Official Full Name: tetraspanin 8provided by RGD
Primary source: RGD:621783
See related: Ensembl:ENSRNOG00000004411 AllianceGenome:RGD:621783
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CO-29; Tm4sf3
Summary: Enables integrin binding activity. Involved in negative regulation of blood coagulation. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Orthologous to human TSPAN8 (tetraspanin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 897.0), Muscle (RPKM 556.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (53331019..53365402)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (51444946..51479360)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (58814805..58847564)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regional expression differences of SERT and TSPAN8 in hippocampus, cerebellum and cortex of wild-type young, adult and middle-aged rats.
Title: Regional expression differences of SERT and TSPAN8 in hippocampus, cerebellum and cortex of wild-type young, adult and middle-aged rats.
Pubertal down-regulation of Tetraspanin 8 in testicular Sertoli cells is crucial for male fertility.
Title: Pubertal down-regulation of Tetraspanin 8 in testicular Sertoli cells is crucial for male fertility.
Tspan8-Tumor Extracellular Vesicle-Induced Endothelial Cell and Fibroblast Remodeling Relies on the Target Cell-Selective Response.
Title: Tspan8-Tumor Extracellular Vesicle-Induced Endothelial Cell and Fibroblast Remodeling Relies on the Target Cell-Selective Response.
Findings show the presence of Tspan8 in breast cancer primary lesion and metastases and indicate its role as a regulator of cell behaviour and extracellular vesicle release in breast cancer. Tspan8 and p120-catenin were co-immunoprecipitated, indicating that they may interact with each other.
Title: Tspan8 is expressed in breast cancer and regulates E-cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles.
Data indicate that the major contribution of cellular tetraspanins CD151 and Tspan8 to lymphatic metastasis formation relies on promoting motility and invasiveness.
Title: The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding.
CD151 and Tspan8 coordinately promote metastasis, where Tspan8 overrides the adhesive features of CD151 by recruiting integrins out of adhesion into motility promoting complexes.
Title: Tspan8 and CD151 promote metastasis by distinct mechanisms.
Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Title: Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
The molecular interactions of D6.1A with multiple proteins in rat tumor cell lines are reported.
Title: The tetraspanin D6.1A and its molecular partners on rat carcinoma cells.

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General gene information

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Markers

BF417031 (e-PCR)
- UniSTS:249653

RH141047 (e-PCR)
- UniSTS:223047

RH141354 (e-PCR)
- UniSTS:223350

RH138974 (e-PCR)
- UniSTS:221060

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of blood coagulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tetraspanin-8

Names: D6.1A; transmembrane 4 superfamily member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133526.2 → NP_598210.1 tetraspanin-8

See identical proteins and their annotated locations for NP_598210.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I5Y9E0, A6IGL6, A6IGL8, O55158

Related

ENSRNOP00000005909.4, ENSRNOT00000005909.7

Conserved Domains (2) summary

cd03154
Location:106 → 204

TM4SF3_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:8 → 228

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

53331019..53365402

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078341.2 → XP_038934269.1 tetraspanin-8 isoform X1

UniProtKB/TrEMBL

A0A8I5Y9E0, A6IGL6, A6IGL8, O55158

Conserved Domains (2) summary

cd03154
Location:106 → 204

TM4SF3_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:8 → 228

Tetraspannin; Tetraspanin family