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    spxA redox-sensitive regulator [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 936407, updated on 12-Feb-2021

    Summary

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    Gene symbol
    spxA
    Gene description
    redox-sensitive regulator
    Locus tag
    BSU_11500
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU11500
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    Genomic context

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    Sequence:
    NC_000964.3 (1227697..1228092)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene putative exporter Neighboring gene putative thiol oxidation management factor; putative acetyltransferase Neighboring gene putative membrane protein of unknown function Neighboring gene hypothetical protein Neighboring gene adaptor protein controlling oligomerization of the AAA+ protein ClpC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spx, the central regulator of the heat and oxidative stress response in B. subtilis, can repress transcription of translation-related genes. Schäfer H, et al. Mol Microbiol, 2019 Feb. PMID 30480837
    2. Geobacillus thermodenitrificans YjbH recognizes the C-terminal end of Bacillus subtilis Spx to accelerate Spx proteolysis by ClpXP. Chan CM, et al. Microbiology (Reading), 2012 May. PMID 22343351, Free PMC Article
    3. Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in Bacillus subtilis. You C, et al. BMC Microbiol, 2008 Jul 28. PMID 18662407, Free PMC Article
    4. Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in Bacillus subtilis. Rochat T, et al. Nucleic Acids Res, 2012 Oct. PMID 22904090, Free PMC Article
    5. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, the authors show that Spx is a central player orchestrating the heat shock response by up-regulating relevant stress response genes as revealed by comparative transcriptomic experiments. Moreover, these experiments revealed the potential of Spx to inhibit transcription of translation-related genes.
      Title: Spx, the central regulator of the heat and oxidative stress response in B. subtilis, can repress transcription of translation-related genes.
    2. Identification of 283 discrete chromosomal sites potentially bound by the Spx-RNA polymerase (Spx-RNAP) complex using chromatin immunoprecipitation of Spx.
      Title: Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in Bacillus subtilis.
    3. GtYjbH enhances ClpXP-catalysed proteolysis of Spx. The C terminus of Spx is required for YjbH binding.
      Title: Geobacillus thermodenitrificans YjbH recognizes the C-terminal end of Bacillus subtilis Spx to accelerate Spx proteolysis by ClpXP.
    4. Oxidative stress induced the expression of msrAB partially through an oxidation on Spx via modification of its CXXC motif.
      Title: Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in Bacillus subtilis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    redox-sensitive regulator
    NP_389032.1
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_389032.1 redox-sensitive regulator [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_389032.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O31602
      Conserved Domains (1) summary
      PRK01655
      Location:1 → 131
      spxA; transcriptional regulator Spx; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O31602.1

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