EGR3 early growth response 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: EGR3provided by HGNC
Official Full Name: early growth response 3provided by HGNC
Primary source: HGNC:HGNC:3240
See related: Ensembl:ENSG00000179388 MIM:602419; AllianceGenome:HGNC:3240
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EGR-3; PILOT
Summary: This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
Expression: Broad expression in gall bladder (RPKM 18.5), brain (RPKM 16.1) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p21.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (22687659..22693480, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (22961911..22967732, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (22545172..22550993, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Early Growth Response 3 in Skin Cancers.
Title: Expression of Early Growth Response 3 in Skin Cancers.
EGR3 and estrone are involved in the tamoxifen resistance and progression of breast cancer.
Title: EGR3 and estrone are involved in the tamoxifen resistance and progression of breast cancer.
Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.
Title: Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.
The EGR3 regulome of infant KMT2A-r acute lymphoblastic leukemia identifies differential expression of B-lineage genes predictive for outcome.
Title: The EGR3 regulome of infant KMT2A-r acute lymphoblastic leukemia identifies differential expression of B-lineage genes predictive for outcome.
XIST promotes apoptosis and the inflammatory response in CSE-stimulated cells via the miR-200c-3p/EGR3 axis.
Title: XIST promotes apoptosis and the inflammatory response in CSE-stimulated cells via the miR-200c-3p/EGR3 axis.
Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro.
Title: Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro.
HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia.
Title: HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia.
Expression and prognostic value of the transcription factors EGR1 and EGR3 in gliomas.
Title: Expression and prognostic value of the transcription factors EGR1 and EGR3 in gliomas.
Silencing of miRNA-210 inhibits the progression of liver cancer and Hepatitis B virus-associated liver cancer via up-regulating EGR3.
Title: Silencing of microRNA-210 inhibits the progression of liver cancer and hepatitis B virus-associated liver cancer via targeting EGR3.
Study demonstrated that EGR3 expression was enhanced in prostate cancer (PC) tissues. EGR3 was proposed as a possible target of miR335, and was negatively regulated by miR335. Silencing EGR3 suppressed the viability and angiogenesis of PC cell line.
Title: Overexpressing miR‑335 inhibits DU145 cell proliferation by targeting early growth response 3 in prostate cancer.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	The gene expression of early growth response 3 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells	PubMed
	tat	HIV-1 Tat (through amino acids 30-40) binds to Egr-3 and synergizes with this protein to super induce the FasL promoter	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G15926 (e-PCR)
- UniSTS:31061

RH141385 (e-PCR)
- UniSTS:223381

WI-15547 (e-PCR)
- UniSTS:83367

RH17894 (e-PCR)
- UniSTS:71358

NoName (e-PCR)
- UniSTS:484342

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in endothelial cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in peripheral nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of gamma-delta T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: early growth response protein 3

Names: zinc finger protein pilot

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199880.2 → NP_001186809.1 early growth response protein 3 isoform 2

See identical proteins and their annotated locations for NP_001186809.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) initiates from a distinct promoter and has a different 5' end, compared to variant (1). It encodes an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC105046, AK294968, AK295134, N66802, S40832, X63741

Consensus CDS

CCDS56528.1

UniProtKB/Swiss-Prot

Q06889

UniProtKB/TrEMBL

B4DH80

Related

ENSP00000430310.1, ENST00000522910.1

Conserved Domains (2) summary

COG5048
Location:265 → 338

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:239 → 261

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001199881.2 → NP_001186810.1 early growth response protein 3 isoform 3

See identical proteins and their annotated locations for NP_001186810.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) initiates from a distinct promoter and has a different 5' end, compared to variant (1). It encodes an isoform (3) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC105046, AK294968, DC333411, N66802, S40832, X63741

UniProtKB/TrEMBL

B4DH80

Conserved Domains (4) summary

COG5048
Location:249 → 305

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:223 → 245

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:221 → 245

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:265 → 290

zf-H2C2_2; Zinc-finger double domain
NM_004430.3 → NP_004421.2 early growth response protein 3 isoform 1

See identical proteins and their annotated locations for NP_004421.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC105046, N66802, S40832, X63741

Consensus CDS

CCDS6033.1

UniProtKB/Swiss-Prot

A8K8U9, B4DHJ5, E7EW38, Q06889, Q2M3W2

Related

ENSP00000318057.2, ENST00000317216.3

Conserved Domains (3) summary

sd00017
Location:277 → 299

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:275 → 299

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:319 → 344

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

22687659..22693480 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011544429.3 → XP_011542731.2 early growth response protein 3 isoform X2
XM_005273425.4 → XP_005273482.1 early growth response protein 3 isoform X1

See identical proteins and their annotated locations for XP_005273482.1

Conserved Domains (5) summary

COG5048
Location:358 → 431

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:332 → 354

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:330 → 354

zf-C2H2; Zinc finger, C2H2 type

pfam11928
Location:142 → 202

DUF3446; Domain of unknown function (DUF3446)

pfam13465
Location:374 → 399

zf-H2C2_2; Zinc-finger double domain