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    DIB1 U4/U6-U5 snRNP complex subunit DIB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856197, updated on 13-Apr-2024

    Summary

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    Gene symbol
    DIB1
    Gene description
    U4/U6-U5 snRNP complex subunit DIB1
    Primary source
    SGD:S000006286
    Locus tag
    YPR082C
    See related
    AllianceGenome:SGD:S000006286
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SNU16
    Summary
    Involved in mRNA splicing, via spliceosome. Part of U4/U6 x U5 tri-snRNP complex and U5 snRNP. Used to study Burn-McKeown syndrome and cancer. Human ortholog(s) of this gene implicated in Burn-McKeown syndrome. Orthologous to human TXNL4A (thioredoxin like 4A). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (704225..704656, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene translation elongation factor EF-1 alpha Neighboring gene putative glycine--tRNA ligase Neighboring gene Mdm36p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional and Biochemical Characterization of Dib1's Role in Pre-Messenger RNA Splicing. Schreib CC, et al. J Mol Biol, 2018 May 25. PMID 29715471, Free PMC Article
    2. Compound heterozygosity of low-frequency promoter deletions and rare loss-of-function mutations in TXNL4A causes Burn-McKeown syndrome. Wieczorek D, et al. Am J Hum Genet, 2014 Dec 4. PMID 25434003, Free PMC Article
    3. The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily. Zhang YZ, et al. Physiol Genomics, 1999 Nov 11. PMID 11015569
    4. Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein. Reuter K, et al. J Mol Biol, 1999 Nov 26. PMID 10610776
    5. An analytical platform for mass spectrometry-based identification and chemical analysis of RNA in ribonucleoprotein complexes. Taoka M, et al. Nucleic Acids Res, 2009 Nov. PMID 19740761, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    U4/U6-U5 snRNP complex subunit DIB1
    NP_015407.1
    • 17-kDa component of the U4/U6aU5 tri-snRNP; plays an essential role in pre-mRNA splicing; human ortholog TXNL4A (the human U5-specific 15-kDa protein) complements yeast dib1 null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      704225..704656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184179.1 → NP_015407.1  TPA: U4/U6-U5 snRNP complex subunit DIB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015407.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W484, Q06819
      UniProtKB/TrEMBL
      A0A8H4F8E1, A6ZWW7, B3LK52, C7GPS5, N1NW30
      Conserved Domains (1) summary
      pfam02966
      Location:5 → 137
      DIM1; Mitosis protein DIM1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3JCM_L.1
    5ZWM_E.1
    5ZWO_E.1
    Q06819.1

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