FCY1 cytosine deaminase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: FCY1
Gene description: cytosine deaminase
Primary source: FungiDB:YPR062W
Locus tag: YPR062W
See related: SGD:S000006266; AllianceGenome:SGD:S000006266
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cytosine deaminase activity. Involved in cytidine metabolic process; cytosine metabolic process; and pyrimidine-containing compound salvage. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FCY1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (677165..677641)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytosine deaminase residue glutamate64 plays a critical role in the activation of anticancer prodrug 5-fluorocytosine, indicating importance not only for the deamination reaction but also for binding of the substrate.
Title: Role of glutamate 64 in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 5-fluorocytosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables cytosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytosine deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables cytosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables deaminase activity	IEA Inferred from Electronic Annotation more info
enables diaminohydroxyphosphoribosylaminopyrimidine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in UMP salvage	IEA Inferred from Electronic Annotation more info
involved_in cytidine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytidine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytosine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytosine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine-containing compound salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine-containing compound salvage	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytosine deaminase

NP_015387.1

EC 3.5.4.1

Cytosine deaminase; zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

677165..677641

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184159.1 → NP_015387.1 TPA: cytosine deaminase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015387.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W467, Q12178

UniProtKB/TrEMBL

A0A6A5Q334, A6ZWV0, B3LLB6, C7GY48, C8ZJ87, G2WPN5, N1P257

Conserved Domains (1) summary

COG0590
Location:6 → 147

TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]