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    MED1 Med1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856183, updated on 3-Mar-2024

    Summary

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    Gene symbol
    MED1
    Gene description
    Med1p
    Primary source
    SGD:S000006274
    Locus tag
    YPR070W
    See related
    AllianceGenome:SGD:S000006274
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable transcription coregulator activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (685898..687598)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene histone deacetylase Neighboring gene spermidine synthase Neighboring gene uncharacterized protein Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C. Hsieh TH, et al. Cell, 2015 Jul 2. PMID 26119342, Free PMC Article
    2. Fungal mediator tail subunits contain classical transcriptional activation domains. Liu Z, et al. Mol Cell Biol, 2015 Apr. PMID 25645928, Free PMC Article
    3. Mediator tail subunits can form amyloid-like aggregates in vivo and affect stress response in yeast. Zhu X, et al. Nucleic Acids Res, 2015 Sep 3. PMID 26138482, Free PMC Article
    4. Functional conservation of the glutamine-rich domains of yeast Gal11 and human SRC-1 in the transactivation of glucocorticoid receptor Tau 1 in Saccharomyces cerevisiae. Kim DH, et al. Mol Cell Biol, 2008 Feb. PMID 18070925, Free PMC Article
    5. The Mediator co-activator complex regulates Ty1 retromobility by controlling the balance between Ty1i and Ty1 promoters. Salinero AC, et al. PLoS Genet, 2018 Feb. PMID 29462141, Free PMC Article

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MED1 is indepently recruited by the activator Met4.
      Title: Independent recruitment of mediator and SAGA by the activator Met4.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Med1p
    NP_015395.1
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      685898..687598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184167.1 → NP_015395.1  TPA: Med1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015395.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W474, Q12321
      UniProtKB/TrEMBL
      A0A8H4BU46, B3LLC3, B5VTL7, C7GY54, C8ZJ95, N1NW26
      Conserved Domains (1) summary
      pfam10744
      Location:12 → 173
      Med1; Mediator of RNA polymerase II transcription subunit 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12321.1

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