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    SRP54 RNA-binding signal recognition particle subunit SRP54 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856203, updated on 13-Apr-2024

    Summary

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    Gene symbol
    SRP54
    Gene description
    RNA-binding signal recognition particle subunit SRP54
    Primary source
    SGD:S000006292
    Locus tag
    YPR088C
    See related
    AllianceGenome:SGD:S000006292
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SRH1
    Summary
    Enables 7S RNA binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane. Located in endoplasmic reticulum. Part of signal recognition particle, endoplasmic reticulum targeting. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (711403..713028, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Asa1p Neighboring gene transcription factor TFIIB Neighboring gene uncharacterized protein Neighboring gene Nvj2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth. Hann BC, et al. J Cell Biol, 1989 Dec. PMID 2557350, Free PMC Article
    2. Isolation of a yeast gene, SRH1, that encodes a homologue of the 54K subunit of mammalian signal recognition particle. Amaya Y, et al. J Biochem, 1990 Mar. PMID 2187859
    3. SRH1 protein, the yeast homologue of the 54 kDa subunit of signal recognition particle, is involved in ER translocation of secretory proteins. Amaya Y, et al. FEBS Lett, 1991 Jun 3. PMID 1646126
    4. Structural and Functional Impact of SRP54 Mutations Causing Severe Congenital Neutropenia. Juaire KD, et al. Structure, 2021 Jan 7. PMID 33053321
    5. The signal recognition particle in S. cerevisiae. Hann BC, et al. Cell, 1991 Oct 4. PMID 1655273

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 7S RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 7S RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 7S RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endoplasmic reticulum signal peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal recognition particle, endoplasmic reticulum targeting IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding signal recognition particle subunit SRP54
    NP_015413.1
    • Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      711403..713028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184185.1 → NP_015413.1  TPA: RNA-binding signal recognition particle subunit SRP54 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015413.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W489, P20424
      UniProtKB/TrEMBL
      A0A6A5Q7H9, A6ZWX2, B5VTN4, C7GPT0, C8ZJB2, G2WPQ7, N1NW32
      Conserved Domains (2) summary
      TIGR01425
      Location:2 → 436
      SRP54_euk; signal recognition particle protein SRP54
      pfam07271
      Location:431 → 484
      Cytadhesin_P30; Cytadhesin P30/P32
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20424.2

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