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    UBA3 NEDD8-activating protein UBA3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856179, updated on 11-Apr-2024

    Summary

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    Gene symbol
    UBA3
    Gene description
    NEDD8-activating protein UBA3
    Primary source
    SGD:S000006270
    Locus tag
    YPR066W
    See related
    AllianceGenome:SGD:S000006270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables NEDD8 activating enzyme activity. Involved in protein neddylation. Located in cytoplasm. Orthologous to human UBA3 (ubiquitin like modifier activating enzyme 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (681213..682112)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rox1p Neighboring gene Isa2p Neighboring gene histone deacetylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes. Hjerpe R, et al. Biochem J, 2012 Feb 1. PMID 22004789, Free PMC Article
    2. A novel protein modification pathway related to the ubiquitin system. Liakopoulos D, et al. EMBO J, 1998 Apr 15. PMID 9545234, Free PMC Article
    3. A dual E3 mechanism for Rub1 ligation to Cdc53. Scott DC, et al. Mol Cell, 2010 Sep 10. PMID 20832729, Free PMC Article
    4. Identification and characterization of genes related to the production of organic acids in yeast. Yoshida S, et al. J Biosci Bioeng, 2012 May. PMID 22277779
    5. A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis. Lissina E, et al. PLoS Genet, 2011 Oct. PMID 22028670, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NEDD8 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NEDD8 activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NEDD8 activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein neddylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein neddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein neddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NEDD8-activating protein UBA3
    NP_015391.1
    • Protein that activates Rub1p (NEDD8) before neddylation; acts together with Ula1p; may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      681213..682112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184163.1 → NP_015391.1  TPA: NEDD8-activating protein UBA3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015391.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W470, E9P8X1, Q99344
      UniProtKB/TrEMBL
      A0A8H4BV14, B3LLB9, C7GY50, C8ZJ91, N1NW24
      Conserved Domains (1) summary
      cd01488
      Location:4 → 294
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99344.1

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