ILK integrin linked kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: ILKprovided by HGNC
Official Full Name: integrin linked kinaseprovided by HGNC
Primary source: HGNC:HGNC:6040
See related: Ensembl:ENSG00000166333 MIM:602366; AllianceGenome:HGNC:6040
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P59; ILK-1; ILK-2; p59ILK; HEL-S-28
Summary: This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression: Ubiquitous expression in endometrium (RPKM 90.1), prostate (RPKM 80.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.4

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (6603774..6610870)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (6662246..6669338)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (6625004..6632101)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrin-linked kinase expression in myeloid cells promotes colon tumorigenesis.
Title: Integrin-linked kinase expression in myeloid cells promotes colon tumorigenesis.
Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis.
Title: Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis.
Substrate Stiffness Regulates the Proliferation and Apoptosis of Periodontal Ligament Cells through Integrin-Linked Kinase ILK.
Title: Substrate Stiffness Regulates the Proliferation and Apoptosis of Periodontal Ligament Cells through Integrin-Linked Kinase ILK.
The Role of Hippo Signaling Pathway and ILK in the Pathophysiology of Human Hypertrophic Scars and Keloids: An Immunohistochemical Investigation.
Title: The Role of Hippo Signaling Pathway and ILK in the Pathophysiology of Human Hypertrophic Scars and Keloids: An Immunohistochemical Investigation.
Identification and validation of EMT-immune-related prognostic biomarkers CDKN2A, CMTM8 and ILK in colon cancer.
Title: Identification and validation of EMT-immune-related prognostic biomarkers CDKN2A, CMTM8 and ILK in colon cancer.
Indoxyl sulfate- and P-cresol-induced monocyte adhesion and migration is mediated by integrin-linked kinase-dependent podosome formation.
Title: Indoxyl sulfate- and P-cresol-induced monocyte adhesion and migration is mediated by integrin-linked kinase-dependent podosome formation.
Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors.
Title: Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors.
Targeting the ILK/YAP axis by LFG-500 blocks epithelial-mesenchymal transition and metastasis.
Title: Targeting the ILK/YAP axis by LFG-500 blocks epithelial-mesenchymal transition and metastasis.
Integrin-linked kinase (ILK): the known vs. the unknown and perspectives.
Title: Integrin-linked kinase (ILK): the known vs. the unknown and perspectives.
Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
Title: Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.

Submit: New GeneRIF Correction See all GeneRIFs (243)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

WI-22555 (e-PCR)
- UniSTS:5777

RH12375 (e-PCR)
- UniSTS:23970

WI-12713 (e-PCR)
- UniSTS:10454

A002C40 (e-PCR)
- UniSTS:5081

KS608 (e-PCR)
- UniSTS:253179

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info
involved_in fibroblast migration	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in myelination in peripheral nervous system	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in nerve development	IEA Inferred from Electronic Annotation more info
involved_in neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in platelet aggregation	HMP more info	PubMed
involved_in positive regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of substrate adhesion-dependent cell spreading	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in focal adhesion	HDA more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sarcomere	IEA Inferred from Electronic Annotation more info
colocalizes_with stress fiber	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: integrin-linked protein kinase

Names: 59 kDa serine/threonine-protein kinase; beta-integrin-linked kinase; epididymis secretory protein Li 28; integrin-linked kinase-2

NP_001014794.1

EC 2.7.11.1

NP_001014795.1

EC 2.7.11.1

NP_001265370.1

EC 2.7.11.1

NP_001265371.1

EC 2.7.11.1

NP_004508.1

EC 2.7.11.1

XP_005252961.1

EC 2.7.11.1

XP_011518367.1

EC 2.7.11.1

XP_024304266.1

EC 2.7.11.1

XP_024304267.1

EC 2.7.11.1

XP_047282841.1

EC 2.7.11.1

XP_054224646.1

EC 2.7.11.1

XP_054224647.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029702.1 RefSeqGene

Range

4975..12142

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_444

mRNA and Protein(s)

NM_001014794.3 → NP_001014794.1 integrin-linked protein kinase isoform 1

See identical proteins and their annotated locations for NP_001014794.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

BC001554, DC380243, HY257434, U40282

Consensus CDS

CCDS7768.1

UniProtKB/Swiss-Prot

B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3

UniProtKB/TrEMBL

A0A0A0MTH3, V9HWF0

Related

ENSP00000403487.2, ENST00000420936.6

Conserved Domains (4) summary

cd14057
Location:197 → 449

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]

pfam13637
Location:4 → 54

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:38 → 124

Ank_2; Ankyrin repeats (3 copies)
NM_001014795.3 → NP_001014795.1 integrin-linked protein kinase isoform 1

See identical proteins and their annotated locations for NP_001014795.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

AC091564, CR749220, DC379936, HY257434, U40282

Consensus CDS

CCDS7768.1

UniProtKB/Swiss-Prot

B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3

UniProtKB/TrEMBL

A0A0A0MTH3, V9HWF0

Related

ENSP00000379975.2, ENST00000396751.6

Conserved Domains (4) summary

cd14057
Location:197 → 449

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]

pfam13637
Location:4 → 54

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:38 → 124

Ank_2; Ankyrin repeats (3 copies)
NM_001278441.2 → NP_001265370.1 integrin-linked protein kinase isoform 2

See identical proteins and their annotated locations for NP_001265370.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate exons in the coding region, which results in a section that contains a frameshift, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC091564, AK296628, DC380243, HY257434, U40282

Consensus CDS

CCDS60712.1

UniProtKB/TrEMBL

A0A0A0MTH3

Related

ENSP00000435323.1, ENST00000528995.5

Conserved Domains (4) summary

cd14057
Location:144 → 388

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]

pfam13637
Location:4 → 54

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:38 → 117

Ank_2; Ankyrin repeats (3 copies)
NM_001278442.2 → NP_001265371.1 integrin-linked protein kinase isoform 3

See identical proteins and their annotated locations for NP_001265371.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, lacks an exon in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK293474

Consensus CDS

CCDS60713.1

UniProtKB/Swiss-Prot

Q13418

Related

ENSP00000434492.2, ENST00000532063.5

Conserved Domains (1) summary

cd14057
Location:63 → 315

PK_ILK; Pseudokinase domain of Integrin Linked Kinase
NM_004517.4 → NP_004508.1 integrin-linked protein kinase isoform 1

See identical proteins and their annotated locations for NP_004508.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

DC380243, HY257434, U40282

Consensus CDS

CCDS7768.1

UniProtKB/Swiss-Prot

B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3

UniProtKB/TrEMBL

A0A0A0MTH3, V9HWF0

Related

ENSP00000299421.4, ENST00000299421.9

Conserved Domains (4) summary

cd14057
Location:197 → 449

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]

pfam13637
Location:4 → 54

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:38 → 124

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

6603774..6610870

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011520065.2 → XP_011518367.1 integrin-linked protein kinase isoform X1

See identical proteins and their annotated locations for XP_011518367.1

UniProtKB/Swiss-Prot

B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3

UniProtKB/TrEMBL

A0A0A0MTH3, V9HWF0

Conserved Domains (4) summary

cd14057
Location:197 → 449

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]

pfam13637
Location:4 → 54

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:38 → 124

Ank_2; Ankyrin repeats (3 copies)
XM_047426885.1 → XP_047282841.1 integrin-linked protein kinase isoform X3
XM_005252904.6 → XP_005252961.1 integrin-linked protein kinase isoform X1

See identical proteins and their annotated locations for XP_005252961.1

UniProtKB/Swiss-Prot

B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3

UniProtKB/TrEMBL

A0A0A0MTH3, V9HWF0

Conserved Domains (4) summary

cd14057
Location:197 → 449

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]

pfam13637
Location:4 → 54

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:38 → 124

Ank_2; Ankyrin repeats (3 copies)
XM_024448499.2 → XP_024304267.1 integrin-linked protein kinase isoform X2

UniProtKB/TrEMBL

A0A0A0MTH3

Conserved Domains (3) summary

cd14057
Location:146 → 398

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:15 → 46

ANK; ANK repeat [structural motif]

pfam12796
Location:2 → 73

Ank_2; Ankyrin repeats (3 copies)
XM_024448498.2 → XP_024304266.1 integrin-linked protein kinase isoform X2

UniProtKB/TrEMBL

A0A0A0MTH3

Conserved Domains (3) summary

cd14057
Location:146 → 398

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:15 → 46

ANK; ANK repeat [structural motif]

pfam12796
Location:2 → 73

Ank_2; Ankyrin repeats (3 copies)