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    YHL012W UTP--glucose-1-phosphate uridylyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856374, updated on 13-Apr-2024

    Summary

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    Gene symbol
    YHL012W
    Gene description
    UTP--glucose-1-phosphate uridylyltransferase
    Primary source
    SGD:S000001004
    Locus tag
    YHL012W
    See related
    AllianceGenome:SGD:S000001004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable UTP:glucose-1-phosphate uridylyltransferase activity. Predicted to be involved in UDP-glucose metabolic process and glycogen metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (78936..80417)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Ylf2p Neighboring gene Otu2p Neighboring gene ribose phosphate diphosphokinase subunit PRS3 Neighboring gene Etp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae VIG9 encodes GDP-mannose pyrophosphorylase, which is essential for protein glycosylation. Hashimoto H, et al. J Biol Chem, 1997 Jun 27. PMID 9195935
    2. Exposing the fitness contribution of duplicated genes. DeLuna A, et al. Nat Genet, 2008 May. PMID 18408719
    3. Multiple knockout analysis of genetic robustness in the yeast metabolic network. Deutscher D, et al. Nat Genet, 2006 Sep. PMID 16941010
    4. Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. Logan MR, et al. BMC Genomics, 2008 Jul 15. PMID 18627629, Free PMC Article
    5. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Johnston M, et al. Science, 1994 Sep 30. PMID 8091229

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables UTP:glucose-1-phosphate uridylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UTP:glucose-1-phosphate uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in glycogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UTP--glucose-1-phosphate uridylyltransferase
    NP_011851.1
    • Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      78936..80417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179092.1 → NP_011851.1  TPA: UTP--glucose-1-phosphate uridylyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011851.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKQ1, P38709
      UniProtKB/TrEMBL
      A0A8H4C1W0, G2WF55
      Conserved Domains (1) summary
      COG4284
      Location:7 → 484
      QRI1; UDP-N-acetylglucosamine pyrophosphorylase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38709.1

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