CTR1 high-affinity Cu transporter CTR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: CTR1
Gene description: high-affinity Cu transporter CTR1
Primary source: SGD:S000006328
Locus tag: YPR124W
See related: AllianceGenome:SGD:S000006328
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables copper ion transmembrane transporter activity. Involved in copper ion import. Located in plasma membrane. Used to study Menkes disease. Orthologous to human SLC31A2 (solute carrier family 31 member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (786208..787428)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EGCG regulates CTR1 expression through its pro-oxidative property in non-small-cell lung cancer cells.
Title: EGCG regulates CTR1 expression through its pro-oxidative property in non-small-cell lung cancer cells.
IGF1R prognosticates prolonged survival in HGSOC patients, possibly due to its positive correlation with hCtr1
Title: IGF1R predicts better survival in high-grade serous epithelial ovarian cancer patients and correlates with hCtr1 levels.
Rho0 cells demonstrated loss of Sco1, resulting in copper deficiency by lowering copper transporter 1 abundance, via mechanism involving increased turnover due to ubiquitination. These findings reveal that a Sco1-dependent mitochondrial signal regulates cellular cisplatin import and cytotoxicity.
Title: Low Ctr1p, due to lack of Sco1p results in lowered cisplatin uptake and mediates insensitivity of rho0 yeast to cisplatin.
Expression of the human copper transporter 1 in SOD1G37R transgenic ALS mice increases copper levels in the spinal cord and restores SOD1 activity.
Title: The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1(G37R) mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1.
Several biological properties of the GST-hNdCTR1 fusion protein were assessed. It was demonstrated that in cells, the protein was prone to oligomerization, formed inclusion bodies and displayed no toxicity. Treatment of E. coli cells with copper and silver ions reduced cell viability in a dose- and time-dependent manner
Title: The Extracellular Domain of Human High Affinity Copper Transporter (hNdCTR1), Synthesized by E. coli Cells, Chelates Silver and Copper Ions In Vivo.
11 single-nucleotide polymorphisms (SNPs) in CTR1, CTR2, ATP7A, and ATP7B were genotyped in these patients.
Title: Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer.
Polymorphism at CTR1 rs12686377 may be associated with toxicity from platinum-based regimens.
Title: Impact of the Copper Transporter Protein 1 (CTR1) Polymorphism on Adverse Events among Advanced NonSmall Cell Lung Cancer Patients Treated with a Carboplatin/Gemcitabine Regimen.
findings show that beta-elemene can block the reduction of CTR1 resulting from oxaliplatin treatment, and therefore has a synergistic anti-hepatocellular carcinoma effect with oxaliplatin by enhancing cellular uptake of oxaliplatin.
Title: β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.
The transition metal ion homeostasis was disrupted in ctr1Delta300 overexpressing strains combined with a transcriptional remodeling of cellular processes.
Title: Overexpression of ctr1Δ300, a high-affinity copper transporter with deletion of the cytosolic C-terminus in Saccharomyces cerevisiae under excess copper, leads to disruption of transition metal homeostasis and transcriptional remodelling of cellular processes.
Deletion of the MAC1 and CTR1 genes involved in copper ion homeostasis exhibited freeze-thaw sensitivity, suggesting that copper ion homeostasis is required for freeze-thaw tolerance.
Title: Insufficiency of copper ion homeostasis causes freeze-thaw injury of yeast cells as revealed by indirect gene expression analysis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables copper ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables copper ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in copper ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in copper ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in copper ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: high-affinity Cu transporter CTR1

NP_015449.1

High-affinity copper transporter of plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress; human homolog SLC31A1 can complement a yeast ctr1 ctr3 double deletion

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

786208..787428

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184221.1 → NP_015449.1 TPA: high-affinity Cu transporter CTR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015449.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W4C2, P49573

UniProtKB/TrEMBL

A0A8H4BV54, A6ZX04, B3LK87, C7GLI6, N1P2D4

Conserved Domains (1) summary

pfam04145
Location:130 → 281

Ctr; Ctr copper transporter family