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    BDKRB1 bradykinin receptor B1 [ Homo sapiens (human) ]

    Gene ID: 623, updated on 2-May-2024

    Summary

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    Official Symbol
    BDKRB1provided by HGNC
    Official Full Name
    bradykinin receptor B1provided by HGNC
    Primary source
    HGNC:HGNC:1029
    See related
    Ensembl:ENSG00000100739 MIM:600337; AllianceGenome:HGNC:1029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B1R; BKR1; B1BKR; BKB1R; BRADYB1
    Summary
    Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. [provided by RefSeq, Aug 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Biased expression in gall bladder (RPKM 7.4), urinary bladder (RPKM 5.2) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    14q32.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (96256210..96264763)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (90487459..90496013)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96722547..96731100)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96563297-96563798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96642023-96642523 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96658061-96658668 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96659886-96660494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96660495-96661102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96661103-96661710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96661711-96662318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96664109-96664715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96670637-96671512 Neighboring gene bradykinin receptor B2 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:96697669-96697864 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96719533-96720042 Neighboring gene uncharacterized LOC124903375 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:96734992-96736191 Neighboring gene NANOG hESC enhancer GRCh37_chr14:96748657-96749197 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38870 Neighboring gene autophagy related 2B Neighboring gene uncharacterized LOC124903430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8985 Neighboring gene Sharpr-MPRA regulatory region 11883 Neighboring gene GSK3B interacting protein Neighboring gene RNA, U2 small nuclear 33, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Correlation of matrix-related airway remodeling and bradykinin B1 receptor expression with fixed airflow obstruction in severe asthma. Bertolini F, et al. Allergy, 2021 Jun. PMID 33284471
    2. Kinin B1 receptor: A target for neuroinflammation in hypertension. Sriramula S. Pharmacol Res, 2020 May. PMID 32087235
    3. The G Allele of the rs12050217 Polymorphism in the BDKRB1 Gene Is Associated with Protection for Diabetic Retinopathy. Brondani LA, et al. Curr Eye Res, 2019 Sep. PMID 31017477
    4. Bradykinin B1 receptor contributes to interleukin-8 production and glioblastoma migration through interaction of STAT3 and SP-1. Liu YS, et al. Neuropharmacology, 2019 Jan. PMID 30366000
    5. Antitumor activity of cell-penetrant kinin B1 receptor antagonists in human triple-negative breast cancer cells. Dubuc C, et al. J Cell Physiol, 2019 Mar. PMID 30132865

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bradykinin-bradykinin receptor (B1R) signalling is involved in the blood-brain barrier disruption in moyamoya disease.
      Title: Bradykinin-bradykinin receptor (B1R) signalling is involved in the blood-brain barrier disruption in moyamoya disease.
    2. Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.
      Title: Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.
    3. The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.
      Title: The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.
    4. Correlation of matrix-related airway remodeling and bradykinin B1 receptor expression with fixed airflow obstruction in severe asthma.
      Title: Correlation of matrix-related airway remodeling and bradykinin B1 receptor expression with fixed airflow obstruction in severe asthma.
    5. Kinin B1 receptor: A target for neuroinflammation in hypertension.
      Title: Kinin B1 receptor: A target for neuroinflammation in hypertension.
    6. The G Allele of the rs12050217 Polymorphism in the BDKRB1 Gene Is Associated with Protection for Diabetic Retinopathy.
      Title: The G Allele of the rs12050217 Polymorphism in the BDKRB1 Gene Is Associated with Protection for Diabetic Retinopathy.
    7. Our work shows for the first time that the interaction between CPM and kinin B1 receptor alters not only B1R pharmacology, but also modulates enzyme expression and activity.
      Title: Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells.
    8. the putative mechanisms underlying the anticancer activities of cell-penetrant B1R antagonists were assessed by analyzing cell cycle regulation and signaling molecules related to cell survival and apoptosis
      Title: Antitumor activity of cell-penetrant kinin B1 receptor antagonists in human triple-negative breast cancer cells.
    9. There is a divergence in BKR1 gene expression in subcutaneous white adipose tissue between patients with and without coronary artery disease and is associated with metabolic parameters.
      Title: Bradykinin receptors gene expression in white adipose tissue in nondiabetic patients with coronary artery disease.
    10. Results indicate that interaction of phosphorylated-STAT3 and acetylated-SP-1 modulates IL-8 expression-mediated glioblastoma migration. The present study also indicates that B1R and the phosphorylated-STAT3/acetylated-SP-1 signaling pathways could serve as therapeutic targets for developing a novel glioblastoma therapy.
      Title: Bradykinin B1 receptor contributes to interleukin-8 production and glioblastoma migration through interaction of STAT3 and SP-1.
    Submit: New GeneRIF Correction See all GeneRIFs (85)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: BDKRB2

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bradykinin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bradykinin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    B1 bradykinin receptor
    Names
    BK-1 receptor
    bradykinin B1 receptor
    bradykinin receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000710.4 → NP_000701.2  B1 bradykinin receptor

      See identical proteins and their annotated locations for NP_000701.2

      Status: REVIEWED

      Source sequence(s)
      AJ238044, AL355102, CB130642
      Consensus CDS
      CCDS9943.1
      UniProtKB/Swiss-Prot
      A8K7F5, P46663, Q546S7, Q8N0Y8
      UniProtKB/TrEMBL
      A0A075E6Y0
      Related
      ENSP00000216629.6, ENST00000216629.11
      Conserved Domains (1) summary
      cd15380
      Location:38 → 323
      7tmA_BK-1; bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001386007.1 → NP_001372936.1  B1 bradykinin receptor

      Status: REVIEWED

      Source sequence(s)
      AL355102
      Consensus CDS
      CCDS9943.1
      UniProtKB/Swiss-Prot
      A8K7F5, P46663, Q546S7, Q8N0Y8
      UniProtKB/TrEMBL
      A0A075E6Y0
      Related
      ENSP00000479276.1, ENST00000611804.1
      Conserved Domains (1) summary
      cd15380
      Location:38 → 323
      7tmA_BK-1; bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      96256210..96264763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      90487459..90496013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46663.3 GenPept UniProtKB/Swiss-Prot:P46663

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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