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GTR Home > Conditions/Phenotypes > Acute lymphoid leukemia


Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). Genetic Heterogeneity of Acute Lymphoblastic Leukemia A susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 (613067), which has been mapped to chromosome 7p12.2; and ALL3 (615545), which is caused by mutation in the PAX5 gene (167414) on chromosome 9p. [from OMIM]

Genes See tests for all associated and related genes

  • Also known as: BCL2L4, BAX
    Summary: BCL2 associated X, apoptosis regulator

  • Also known as: ALL, BCR1, CML, D22S11, D22S662, PHL, BCR
    Summary: BCR activator of RhoGEF and GTPase

  • Also known as: CD135, FLK-2, FLK2, STK1, FLT3
    Summary: fms related receptor tyrosine kinase 3

  • Also known as: HG2A, MDS, MRD42, GNB1
    Summary: G protein subunit beta 1

  • Also known as: AT-V1, AT-V2, ATV, NBS, NBS1, P95, NBN
    Summary: nibrin

  • Also known as: CAIN, CAN, IIAE9, NUP214
    Summary: nucleoporin 214

  • Also known as: SCL, TCL5, bHLHa17, tal-1, TAL1
    Summary: TAL bHLH transcription factor 1, erythroid differentiation factor

  • Also known as: , TAL2
    Summary: TAL bHLH transcription factor 2

Clinical features


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