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GTR Home > Conditions/Phenotypes > Dilated cardiomyopathy 1D

Dilated cardiomyopathy 1D

Synonyms
Left ventricular noncompaction 6; TNNT2-Related Dilated Cardiomyopathy

Summary

Left ventricular noncompaction is a heart (cardiac) muscle disorder that occurs when the lower left chamber of the heart (left ventricle), which helps the heart pump blood, does not develop correctly. Instead of the muscle being smooth and firm, the cardiac muscle in the left ventricle is thick and appears spongy. The abnormal cardiac muscle is weak and has an impaired ability to pump blood because it either cannot completely contract or it cannot completely relax. For the heart to pump blood normally, cardiac muscle must contract and relax fully.\n\nSome individuals with left ventricular noncompaction experience no symptoms at all; others have heart problems that can include sudden cardiac death. Additional signs and symptoms include abnormal blood clots, irregular heart rhythm (arrhythmia), a sensation of fluttering or pounding in the chest (palpitations), extreme fatigue during exercise (exercise intolerance), shortness of breath (dyspnea), fainting (syncope), swelling of the legs (lymphedema), and trouble laying down flat. Some affected individuals have features of other heart defects. Left ventricular noncompaction can be diagnosed at any age, from birth to late adulthood. Approximately two-thirds of individuals with left ventricular noncompaction develop heart failure. [from MedlinePlus Genetics]

Available tests

79 tests are in the database for this condition.

Check Related conditions for additional relevant tests.

Clinical tests (79 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT, TNNT2
    Summary: troponin T2, cardiac type

Clinical features

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Imported from Human Phenotype Ontology (HPO)

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