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GTR Home > Conditions/Phenotypes > Taurodontism, microdontia, and dens invaginatus

Taurodontism, microdontia, and dens invaginatus

Summary

Taurodontism, microdontia, and dens invaginatus (TMDI) is an X-linked recessive disorder in which affected individuals exhibit generalized abnormally small teeth, with molars that have a crown and pulp chamber that are disproportionately and vertically longer than the roots (taurodontism). In addition, multiple teeth exhibit dens invaginatus, the formation of a tooth within a tooth, resulting either from the dental papilla folding into the developing tooth or the enamel folding into the dental papilla (Casamassimo et al., 1978; Gowans et al., 2019). [from OMIM]

Genes See tests for all associated and related genes

  • Also known as: KIF4, KIF4G1, MRX100, TMDI, XLID100, KIF4A
    Summary: kinesin family member 4A

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