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GTR Home > Conditions/Phenotypes > Hepatocellular carcinoma


Hepatocellular carcinoma is the major histologic type of malignant primary liver neoplasm. It is the fifth most common cancer and the third most common cause of death from cancer worldwide. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Hepatoblastomas comprise 1 to 2% of all malignant neoplasms of childhood, most often occurring in children under 3 years of age. Hepatoblastomas are thought to be derived from undifferentiated hepatocytes (Taniguchi et al., 2002). [from OMIM]

Genes See tests for all associated and related genes

  • Also known as: BTPS2, DESMD, DP2, DP2.5, DP3, GS, PPP1R46, APC
    Summary: APC regulator of WNT signaling pathway

  • Also known as: AXIN, CMDOH, PPP1R49, AXIN1
    Summary: axin 1

  • Also known as: ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5, CASP8
    Summary: caspase 8

  • Also known as: CTNNB, EVR7, MRD19, NEDSDV, armadillo, CTNNB1
    Summary: catenin beta 1

  • Also known as: CD222, CI-M6PR, CIMPR, M6P-R, M6P/IGF2R, MPR 300, MPR1, MPR300, MPRI, IGF2R
    Summary: insulin like growth factor 2 receptor

  • Also known as: AUTS9, DA11, DFNB97, HGFR, RCCP2, c-Met, MET
    Summary: MET proto-oncogene, receptor tyrosine kinase

  • Also known as: PDGRL, PRLTS, PDGFRL
    Summary: platelet derived growth factor receptor like

  • Also known as: CCM4, CLAPO, CLOVE, CWS5, HMH, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha, PIK3CA
    Summary: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

  • Also known as: BCC7, BMFS5, LFS1, P53, TRP53, TP53
    Summary: tumor protein p53

Clinical features


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