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GTR Home > Conditions/Phenotypes > Indifference to pain, congenital, autosomal dominant

Indifference to pain, congenital, autosomal dominant

Synonyms
CONGENITAL ANALGESIA, AUTOSOMAL DOMINANT

Summary

Marsili syndrome (MARSIS) is an autosomal dominant pain insensitivity disorder characterized by a lowered ability to sense pain, to experience temperature, and to sweat. Affected individuals do not perceive broken bones and burns as painful, and have lowered sensitivity to capsaicin. However, visceral pain (e.g., childbirth-related) and light touch are perceived (summary by Habib et al., 2018). [from OMIM]

Available tests

1 test is in the database for this condition.

Clinical tests (1 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: MARSIS, ZFH-5, ZFH5, ZNF409, ZFHX2
    Summary: zinc finger homeobox 2

Clinical features

Help
Imported from Human Phenotype Ontology (HPO)

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