U.S. flag

An official website of the United States government

GTR Home > Genes

CEBPA CCAAT enhancer binding protein alpha

Gene ID: 1050, updated on 23-Mar-2024
Gene type: protein coding
Also known as: CEBP; C/EBP-alpha


This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]

Copy number response

Copy number response

No evidence available (Last evaluated 2022-06-09)

ClinGen Genome Curation Page

No evidence available (Last evaluated 2022-06-09)

ClinGen Genome Curation Page

Genomic context

Chromosome: 19; NC_000019.10 (33299934..33302534, complement)
Total number of exons:


IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.