DCC DCC netrin 1 receptor
Gene ID: 1630, updated on 17-Jun-2024Gene type: protein coding
Also known as: CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1
- See all available tests in GTR for this gene
- Go to complete Gene record for DCC
- Go to Variation Viewer for DCC variants
Summary
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population. GeneReviews: Not available | |
| A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. GeneReviews: Not available | |
| Colorectal cancer | See labs |
| Gaze palsy, familial horizontal, with progressive scoliosis, 2 | See labs |
| Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. GeneReviews: Not available | |
| Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. GeneReviews: Not available | |
| Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system. GeneReviews: Not available | |
| Malignant tumor of esophagus | See labs |
| Mirror movements 1 | See labs |
| Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. GeneReviews: Not available |
Genomic context
- Location:
- 18q21.2
- Sequence:
- Chromosome: 18; NC_000018.10 (52340197..53535899)
- Total number of exons:
- 31
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for DCC variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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