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ADNP activity dependent neuroprotector homeobox

Gene ID: 23394, updated on 3-Apr-2024
Gene type: protein coding
Also known as: ADNP1; HVDAS; MRD28

Summary

Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
GeneReviews: Not available
ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder
MedGen: C4014538OMIM: 615873GeneReviews: ADNP-Related Disorder
See labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2017-11-22)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2017-11-22)

ClinGen Genome Curation PagePubMed

Genomic context

Location:
20q13.13
Sequence:
Chromosome: 20; NC_000020.11 (50888918..50931437, complement)
Total number of exons:
8

Links

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