U.S. flag

An official website of the United States government

GTR Home > Genes

GRIA1 glutamate ionotropic receptor AMPA type subunit 1

Gene ID: 2890, updated on 28-Oct-2024
Gene type: protein coding
Also known as: GLUH1; GLUR1; GLURA; GluA1; HBGR1; MRD67; MRT76

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
A genome-wide association study of aging.
GeneReviews: Not available
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.
GeneReviews: Not available
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available
Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
GeneReviews: Not available
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
GeneReviews: Not available
Intellectual developmental disorder, autosomal dominant 67
MedGen: C5677006OMIM: 619927GeneReviews: Not available
See labs
Intellectual developmental disorder, autosomal recessive 76
MedGen: C5677007OMIM: 619931GeneReviews: Not available
See labs
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Genomic context

Location:
5q33.2
Sequence:
Chromosome: 5; NC_000005.10 (153489615..153813869)
Total number of exons:
21

Links

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.