ICOS inducible T cell costimulator
Gene ID: 29851, updated on 22-Apr-2024Gene type: protein coding
Also known as: AILIM; CD278; CVID1
- See all available tests in GTR for this gene
- Go to complete Gene record for ICOS
- Go to Variation Viewer for ICOS variants
Summary
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. GeneReviews: Not available | |
| Immunodeficiency, common variable, 1 | See labs |
| Immunodeficiency, common variable, 2 | See labs |
| Multiple common variants for celiac disease influencing immune gene expression. GeneReviews: Not available | |
| Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. GeneReviews: Not available |
Genomic context
- Location:
- 2q33.2
- Sequence:
- Chromosome: 2; NC_000002.12 (203936763..203961577)
- Total number of exons:
- 7
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for ICOS variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- ICOS database
- ICOSbase: Mutation registry for ICOS deficiency
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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