ADGRE2 adhesion G protein-coupled receptor E2
Gene ID: 30817, updated on 2-Nov-2024Gene type: protein coding
Also known as: VBU; CD97; EMR2; CD312
Summary
This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Associated conditions
| Description | Tests |
|---|---|
| Vibratory urticaria | not available |
Genomic context
- Location:
- 19p13.12
- Sequence:
- Chromosome: 19; NC_000019.10 (14724171..14778560, complement)
- Total number of exons:
- 26
Variation
| Resource | Links for this gene |
|---|---|
| SNP | Variation Viewer for ADGRE2 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
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