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DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory

Gene ID: 8818, updated on 17-Jun-2024
Gene type: protein coding
Also known as: CDG1U

Summary

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]

Genomic context

Location:
9q34.11
Sequence:
Chromosome: 9; NC_000009.12 (127935099..127937854, complement)
Total number of exons:
5

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