CYP2C19 cytochrome P450 family 2 subfamily C member 19
Gene ID: 1557, updated on 25-Apr-2024Gene type: protein coding
Also known as: CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19
- See all available tests in GTR for this gene
- Go to complete Gene record for CYP2C19
- Go to Variation Viewer for CYP2C19 variants
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide association study of acenocoumarol maintenance dosage. GeneReviews: Not available | |
| Amitriptyline response MedGen: CN176769GeneReviews: Not available | See labs |
| An atlas of genetic influences on human blood metabolites. GeneReviews: Not available | |
| Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. GeneReviews: Not available | |
| Brivaracetam response MedGen: CN781941GeneReviews: Not available | See labs |
| Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. GeneReviews: Not available | |
| Citalopram response MedGen: CN221263GeneReviews: Not available | See labs |
| Clobazam response MedGen: CN456489GeneReviews: Not available | See labs |
| Clopidogrel response MedGen: C2674941GeneReviews: Not available | See labs |
| Clozapine response MedGen: CN077971GeneReviews: Not available | See labs |
| CYP2C19-related poor drug metabolism | See labs |
| Dexlansoprazole response MedGen: CN474479GeneReviews: Not available | See labs |
| Doxepin response MedGen: CN077978GeneReviews: Not available | See labs |
| Escitalopram response MedGen: CN221264GeneReviews: Not available | See labs |
| Esomeprazole response MedGen: CN077982GeneReviews: Not available | See labs |
| Flibanserin response MedGen: CN507895GeneReviews: Not available | See labs |
| Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. GeneReviews: Not available | |
| Genome-wide meta-analysis identifies new susceptibility loci for migraine. GeneReviews: Not available | |
| Imipramine response MedGen: CN221257GeneReviews: Not available | See labs |
| Lacosamide response MedGen: CN781942GeneReviews: Not available | See labs |
| Lansoprazole response MedGen: CN474477GeneReviews: Not available | See labs |
| Pantoprazole response MedGen: CN474478GeneReviews: Not available | See labs |
| Selective serotonin reuptake inhibitor response MedGen: CN221268GeneReviews: Not available | See labs |
| Sertraline response MedGen: CN221265GeneReviews: Not available | See labs |
| Trimipramine response MedGen: CN221259GeneReviews: Not available | See labs |
| Voriconazole response MedGen: CN077957GeneReviews: Not available | See labs |
Genomic context
- Location:
- 10q23.33
- Sequence:
- Chromosome: 10; NC_000010.11 (94762681..94855547)
- Total number of exons:
- 9
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for CYP2C19 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- CYP2C19 database
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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