APC Resistance Profile with Reflex to Factor V Leiden
GTR Test Accession: Help GTR000500421.3
NYS CLEP
HEMATOLOGY
Last updated in GTR: 2023-07-31
Last annual review date for the lab: 2023-07-17 LinkOut
At a Glance
Diagnosis; Screening
Thrombophilia
Genes (1): Help
F5 (1q24.2)
Vitamin K-dependent protein C
Biochemical Genetics - Analyte: Clotting; ...
Initial screening for patients with suspected thrombophilia
Not provided
Not provided
Ordering Information
Offered by: Help
ARUP Laboratories, Molecular Genetics and Genomics
View lab's website
View lab's test page
Test short name: Help
APC R
Specimen Source: Help
Who can order: Help
  • Genetic Counselor
  • Health Care Provider
  • Licensed Dentist
  • Licensed Physician
  • Nurse Practitioner
  • Physician Assistant
  • Public Health Mandate
  • Registered Nurse
Test Order Code: Help
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
Collect: Lt. blue (sodium citrate) AND lavender (EDTA), pink (K2EDTA), or yellow (ACD Solution A or B). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation: Transport 1.5 mL platelet-poor plasma AND 3 mL whole blood. (Min: 1 mL/each)

Storage/Transport Temperature: Plasma: Frozen. Whole …
View more
Order URL
Informed consent required: Help
Based on applicable state law
Test strategy: Help
Ratios less than 2.00 suggest APC resistance. This method uses factor V deficient plasma; therefore, APC resistance due to a nonfactor V mutation will not be detected. Extreme factor V deficiency may cause abnormal ratio. Note: If APC resistance is normal, then no further testing will be added. If APC … View more
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
Conditions Help
Total conditions: 1
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 1
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Proteins Help
Total proteins: 1
Protein Associated Condition
Methodology
Total methods: 2
Method Category Help
Test method Help
Instrument *
Analyte
Clotting
Targeted variant analysis
Polymerase Chain Reaction/Fluorescence Monitoring
* Instrument: Not provided
Clinical Information
Test purpose: Help
Diagnosis; Screening
Target population: Help
Initial screening for patients with suspected thrombophilia
View citations (1)
  • http://www.arupconsult.com/Topics/Thrombophilia.html?client_ID=LTD#tabs=3
Variant Interpretation:
What is the protocol for interpreting a variation as a VUS? Help
N/A

Are family members with defined clinical status recruited to assess significance of VUS without charge? Help
N/A

Will the lab re-contact the ordering physician if variant interpretation changes? Help
Not provided. N/A
Research:
Is research allowed on the sample after clinical testing is complete? Help
N/A
Recommended fields not provided:
Technical Information
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
Component Component Factor V Leiden (F5) R506Q Mutation: Analytical sensitivity and specificity: 99%.
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Intra-Laboratory
VUS:
Software used to interpret novel variations Help
N/A

Laboratory's policy on reporting novel variations Help
N/A
Recommended fields not provided:
Regulatory Approval
FDA Review: Help
Not provided
NYS CLEP Approval: Help
Number: 4196
Status: Approved
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.