Cardiac Diseases Gene panel
- GTR Test IDHelpEach Test is a specific, orderable test from a particular laboratory, and is assigned a unique GTR accession number. The format is GTR00000001.1, with a leading prefix 'GTR' followed by 8 digits, a period, then 1 or more digits representing the version. When a laboratory updates a registered test, a new version number is assigned.: GTR000515873.3
- Last updated: 2022-04-08
- Annual Review past due read more
- Test version history
Clinical testHelpIn the U.S., clinical tests must be performed under CLIA certification. When a lab uses the same methods for a test in both clinical and research settings, the test appears as two separate GTR records. for Cardiac arrhythmia
Offered by Clinical and Translational Genomics Laboratory
Overview
Test name
HelpThe name the laboratory assigns the test. Used as the default title of the page specific to the test.Cardiac Diseases Gene panel
This is a clinical test intended for HelpPurposes or indications for the test. Lab-provided.: Diagnosis, Prognostic
Click Indication tab for more information.
To order a test, complete and submit a requisition form that can be found on our website (gps.wustl.edu)
Order URL HelpLink to the laboratory webpage with information about how to order this test. Please note that clicking on this link will open a new tab in your internet browser.: http://gps.wustl.edu/
Specimen source
Methodology
HelpThe assay's major method category (biochemical, cytogenetic or molecular genetics); method category (i.e. enzyme assay, chromosome breakage studies, targeted mutation analysis); methodology (i.e. the name of the method used) and instruments used when performing this test.- Molecular Genetics
- CSequence analysis of the entire coding region
- Next-Generation (NGS)/Massively parallel sequencing (MPS)
Not provided
Clinical validity
HelpHow consistently and accurately the test detects or predicts the intermediate or final outcomes of interest. Lab-provided.Not provided
Testing strategy
HelpThe lab's suggested sequence of ordering tests based on clinical scenarios. It may include information on: reflex testing including each test component, and scenarios which prompt additional components of testing; whether lab communicates interim results or automatically proceeds to further analyses; and if any components are performed in another laboratory.Testing is performed by exome capture of the coding regions of relevant genes followed by next generation sequencing to detect small sequence variants. Starred tests (*) include additional testing for deletions and duplications by an alternate methodology (aCGH) when sequencing does not identify genetic variation consistent with a molecular diagnosis. Core gene panels are comprised of genes established as causal for the relevant clinical condition. Expanded gene panels include all genes found in the core panel plus additional genes of uncertain significance that are implicated as candidate genes for the condition. ***Please note that when a CORE panel is ordered, only the core panel genes will be analyzed and reported. When an EXPANDED panel is ordered, the core panel genes will be analyzed first for clinically significant variation. If no molecular diagnosis is made, the analysis will then extend to the expanded gene set, which includes genes of uncertain significance that have been implicated in the relevant conditions. 000 To order a test, complete and submit a requisition form that can be found on our website (gps.wustl.edu)
Test services
HelpLaboratory's order or catalog code for the test (used in the order requisition form).- Clinical Testing/Confirmation of Mutations Identified Previously
IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.