Multiple Myeloma Microarray+FISH Panel on CD138 Purified Plasma Cells
GTR Test Accession: Help GTR000527620.2
IMMUNOLOGYINHERITED DISEASECANCER ... View more
Last updated in GTR: 2017-09-25
Last annual review date for the lab: 2023-05-22 LinkOut
At a Glance
Diagnosis; Prognostic; Risk Assessment
Multiple myeloma
13q-; 1p- (CDKN2C, FAM46C); 1q+ (CKS1B); 8q24 (MYC); IGH/CCND1 translocation; ...
Genes (1): Help
IGH (14q32.33)
Cytogenetics - FISH-interphase: Fluorescence in situ hybridization (FISH); ...
Individuals with multifocal clonal proliferation of plasma cells based on …
Not provided
Not provided
Ordering Information
Offered by: Help
Pittsburgh Cytogenetics Laboratory
View lab's website
View lab's test page
Specimen Source: Help
Who can order: Help
  • Health Care Provider
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
For more information, please contact the laboratory directly.
Order URL
Test development: Help
Test developed by laboratory (no manufacturer test name)
Informed consent required: Help
Decline to answer
Test strategy: Help
FISH analysis on a population of the CD138 positive purified plasma cells to provide diagnostic and prognostic information that is routinely used in diagnosis and risk stratification for treatment in multiple myeloma.
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
Conditions Help
Total conditions: 1
Condition/Phenotype Identifier
Test Targets
Chromosomal regions/Mitochondria Help
Total chromosomal regions/mitochondria: 9
Chromosomal region/Mitochondrion Associated condition
Genes Help
Total genes: 1
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Methodology
Total methods: 2
Method Category Help
Test method Help
Instrument
FISH-interphase
Fluorescence in situ hybridization (FISH)
Deletion/duplication analysis
Microarray
Agilent SureSelect
Clinical Information
Test purpose: Help
Diagnosis; Prognostic; Risk Assessment
Target population: Help
Individuals with multifocal clonal proliferation of plasma cells based on the bone marrow analysis
Recommended fields not provided:
Technical Information
Test Platform:
Agilent SurePrint G3 Human CGH Microarray Kit, 2x400K
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
This whole genome microarray + FISH panel will detect gains, losses, and translocations involving targeted loci. This assay is sensitive to detect chromosome aberrations present in at least 30% of plasma cells expressing CD138 marker. If more information is needed, please contact the laboratory directly.
Assay limitations: Help
The low percentage of plasma cells (less than 1%) in the bone marrow aspirate may yield insufficient number of cells for FISH analysis.
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
No
Recommended fields not provided:
Regulatory Approval
FDA Review: Help
Category: FDA exercises enforcement discretion
Additional Information

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