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GTR Home > Tests > Preimplantation genetic screening by microarray


Test name


Preimplantation genetic screening by microarray (PGS microarray)

Purpose of the test


This is a clinical test intended for Help: Pre-implantation genetic diagnosis, Screening



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How to order


For more information, please contact the laboratory directly.
Order URL Help: http://www.upmc.com/locations/hospitals/magee/services/center-for-fertility-and-reproductive-endocrinology


Molecular Genetics
DDeletion/duplication analysis
  • Agilent SureSelect
  • Agilent SurePrint G3 Human CGH Microarray Kit, 2x400K

Summary of what is tested

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Click Methodology tab for more information.

Clinical utility


Reproductive decision-making

  • Two different microarray technologies for preimplantation genetic diagnosis and screening, due to reciprocal translocation imbalances, demonstrate equivalent euploidy and clinical pregnancy rates. - PubMed ID: 24771116

Clinical validity


Not provided

Testing strategy


Standard In vitro fertilization and embryo transfer (IVF-ET) involves controlled ovarian hyperstimulation to obtain multiple (6-12) mature oocytes, in vitro fertilization, and culturing to the blastocyst stage (70-120 cells) by day 5 after fertilization. These procedures can be performed at the Center for Fertility and Reproductive Endocrinology at Magee-Womens Hospital​. In average 40% of all IVF embryos appear normal, but still have a whole chromosome abnormality. The ultimate goal of IVF-ET is to identify chromosomally normal embryos by preimplantation genetic screening (PGS) and to perform a single embryo transfer. PGS involves removing 4-6 placental cells from normal appearing blastocysts. The biopsy samples are then subject to DNA amplification and then microarray comparative genomic hybridization to determine if the blastocyst is euploid or aneuploid. Transfer of a single chromosomally normal embryo improves the odds that in vitro fertilization procedure will result in a live born child and reduces the risk of complications associated with multi-fetal pregnancy. 000 For more information, please contact the laboratory directly.

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.