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Mismatch Repair Proteins by Immunohistochemistry
Clinical Genetic Test
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offered by
GoPath Diagnostics
View lab's test page
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GTR Test Accession: Help GTR000591173.1
INHERITED DISEASECANCERDIGESTIVE SYSTEM ... View more
Last updated in GTR: 2020-07-01
View version history
Last annual review date for the lab: 2023-06-14 LinkOut
At a Glance
Test purpose: Help
Diagnosis; Screening
Conditions (6): Help
Lynch syndrome; Carcinoma of colon; Familial adenomatous polyposis 1; ...
Enzymes (1): Help
Mismatch repair endonuclease PMS2
Proteins (3): Help
DNA mismatch repair protein Mlh1; DNA mismatch repair protein Msh2; DNA mismatch repair protein Msh6
Methods (1): Help
Biochemical Genetics - Immunohistochemistry: Antibody detection
Target population: Help
patients who show symptoms of lynch syndrome/HPNCC
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
GoPath Diagnostics
View lab's website
View lab's test page
Test short name: Help
MMR IHC
Specimen Source: Help
Who can order: Help
  • Health Care Provider
  • Licensed Physician
Test Order Code: Help
IHC for MLH1, MSH2, MSH6, PMS2
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
use the IHC requisition form and select the proteins you want stained by IHC

CPT codes are 88342 x1, and 88341 x3
Order URL
Test service: Help
Immunohistochemistry
    OrderCode: 88342x1, 88341x3
Informed consent required: Help
No
Pre-test genetic counseling required: Help
No
Post-test genetic counseling required: Help
No
Recommended fields not provided:
Lab contact for this test, Test strategy, Test development
Conditions Help
Total conditions: 6
Condition/Phenotype Identifier
Test Targets
Enzymes Help
Total enzymes: 1
Enzyme Associated Condition
Proteins Help
Total proteins: 3
Protein Associated Condition
Methodology
Total methods: 1
Method Category Help
Test method Help
Instrument
Immunohistochemistry
Antibody detection
LABVISION 360 AUTOSTAINER
Clinical Information
Test purpose: Help
Diagnosis; Screening
Target population: Help
patients who show symptoms of lynch syndrome/HPNCC
Variant Interpretation:
What is the protocol for interpreting a variation as a VUS? Help
N/A

Are family members with defined clinical status recruited to assess significance of VUS without charge? Help
No.

Will the lab re-contact the ordering physician if variant interpretation changes? Help
Not provided. our GeneticsNow service covers it all - please use our website www.gopathlabs.com
Recommended fields not provided:
Clinical validity, Clinical utility, Will the lab re-contact the ordering physician if variant interpretation changes?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Test Platform:
None/not applicable
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
control slides are used with each stain procedure. based on if the control is valid or not, the test performed for the batch of slides are valid or invalid. when the control is valid, accuracy and precision is 100%.
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Formal PT program

PT Provider: Help
CAP
VUS:
Software used to interpret novel variations Help
N/A

Laboratory's policy on reporting novel variations Help
formal reports
Recommended fields not provided:
Test Confirmation, Assay limitations, Description of internal test validation method, Citations for Analytical validity, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Not provided
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.