TTN panel
- GTR Test IDHelpEach Test is a specific, orderable test from a particular laboratory, and is assigned a unique GTR accession number. The format is GTR00000001.1, with a leading prefix 'GTR' followed by 8 digits, a period, then 1 or more digits representing the version. When a laboratory updates a registered test, a new version number is assigned.: GTR000591294.2
- Last updated: 2023-08-09
- Test version history
Clinical testHelpIn the U.S., clinical tests must be performed under CLIA certification. When a lab uses the same methods for a test in both clinical and research settings, the test appears as two separate GTR records. for Primary dilated cardiomyopathy
Offered by Molecular Cardiology Laboratories
Overview
Test name
HelpThe name the laboratory assigns the test. Used as the default title of the page specific to the test.TTN panel (TTN)
This is a clinical test intended for HelpPurposes or indications for the test. Lab-provided.: Diagnosis, Predictive, Risk Assessment
Click Indication tab for more information.
Tests can be referred to the lab either directly by patient/family or by referring physician. The first step will be to contact the Genetic counselor or the medical director of the lab to have detailed instruction that vary upon the specific test that is requested.
Since the Lab work in conjunction with an outpatient clinic for inherited arrhythmogenic diseases the test can also be requested directly from the Molecular Cardiology team members.
Specimen source
Methodology
HelpThe assay's major method category (biochemical, cytogenetic or molecular genetics); method category (i.e. enzyme assay, chromosome breakage studies, targeted mutation analysis); methodology (i.e. the name of the method used) and instruments used when performing this test.- Molecular Genetics
- SMutation scanning of the entire coding region
- Next-Generation (NGS)/Massively parallel sequencing (MPS)
- Thermofisher Ion Torrent
Guidance for management
- Prognostic implications of pathogenic truncating variants in the TTN gene. - PubMed ID: 32371228
Clinical validity
HelpHow consistently and accurately the test detects or predicts the intermediate or final outcomes of interest. Lab-provided.Not provided
Testing strategy
HelpThe lab's suggested sequence of ordering tests based on clinical scenarios. It may include information on: reflex testing including each test component, and scenarios which prompt additional components of testing; whether lab communicates interim results or automatically proceeds to further analyses; and if any components are performed in another laboratory.NGS targeted panel This test is usually performed if standard DCM panel is negative for causative mutations 000 Tests can be referred to the lab either directly by patient/family or by referring physician. The first step will be to contact the Genetic counselor or the medical director of the lab to have detailed instruction that vary upon the specific test that is requested. Since the Lab work in conjunction with an outpatient clinic for inherited arrhythmogenic diseases the test can also be requested directly from the Molecular Cardiology team members.
Test services
HelpLaboratory's order or catalog code for the test (used in the order requisition form).- Clinical Testing/Confirmation of Mutations Identified Previously
- Confirmation of research findings
- Genetic counseling
- Result interpretation
- OMIM
- View ACTC1 variations in ClinVar
- View ACTN2 variations in ClinVar
- View DES variations in ClinVar
- View DSG2 variations in ClinVar
- View EYA4 variations in ClinVar
- View FKTN variations in ClinVar
- View LMNA variations in ClinVar
- View MYBPC3 variations in ClinVar
- View MYH6 variations in ClinVar
- View PLN variations in ClinVar
- View PSEN1 variations in ClinVar
- View PSEN2 variations in ClinVar
- View SGCD variations in ClinVar
- View TAFAZZIN variations in ClinVar
- View TMPO variations in ClinVar
- View TNNT2 variations in ClinVar
- View TPM1 variations in ClinVar
- View TTN variations in ClinVar
- View VCL variations in ClinVar
- View CSRP3 variations in ClinVar
- View TCAP variations in ClinVar
- View BAG3 variations in ClinVar
- View ABCC9 variations in ClinVar
- View LDB3 variations in ClinVar
- View ANKRD1 variations in ClinVar
- View NEXN variations in ClinVar
- View RBM20 variations in ClinVar
- RefSeqGene
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