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GTR Home > Tests > Hereditary Hemolytic Anemia Cascade

Overview

Test order codeHelp: 3000894

Test name

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Hereditary Hemolytic Anemia Cascade

Purpose of the test

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This is a clinical test intended for Help: Diagnosis, Monitoring, Mutation Confirmation, Predictive, Prognostic, Recurrence, Risk Assessment, Screening

Condition

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How to order

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Order URL Help: https://ltd.aruplab.com/Tests/Pub/3000894

Specimen source

Peripheral (whole) blood

Methodology

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Molecular Genetics
DDeletion/duplication analysis
Multiplex Ligation-dependent Probe Amplification (MLPA)
CSequence analysis of the entire coding region
Bi-directional Sanger Sequence AnalysisNext-Generation (NGS)/Massively parallel sequencing (MPS)

Summary of what is tested

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Clinical utility

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Not provided

Clinical validity

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Not provided

Testing strategy

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Reflexive testing. A faculty hematopathologist personally directs and interprets each stage of testing to completion. Cascade components which are always performed are: Blood Smear with Interpretation; Osmotic Fragility, Erythrocyte; Hemoglobin, Unstable; Hemoglobin Evaluation with Reflex to Electrophoresis and/or RBC Solubility RBC Band 3 Protein Reduction in Hereditary Spherocytosis; Glucose-6-Phosphate Dehydrogenase; Pyruvate Kinase. Molecular testing of HBB, HBA1, HBA2, G6PD, and other genes associated with hereditary hemolytic anemia may be performed as needed. A comprehensive report is provided after all testing is completed. 000 Reflexive testing. A faculty hematopathologist personally directs and interprets each stage of testing to completion. Cascade components which are always performed are: Blood Smear with Interpretation; Osmotic Fragility, Erythrocyte; Hemoglobin, Unstable; Hemoglobin Evaluation with Reflex to Electrophoresis and/or RBC Solubility RBC Band 3 Protein Reduction in Hereditary Spherocytosis; Glucose-6-Phosphate Dehydrogenase; Pyruvate Kinase. Molecular testing of HBB, HBA1, HBA2, G6PD, and other genes associated with hereditary hemolytic anemia may be performed as needed. A comprehensive report is provided after all testing is completed.

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